May be useful in the comprehensive evaluation of patients with autoimmune neuropathies. Test by itself is not diagnostic and should be used in conjunction with other clinical parameters to confirm disease.
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Mon, Wed, Fri
Serum separator tube.
Separate serum from cells ASAP. Transfer 0.3 mL serum to an ARUP Standard Transport Tube. (Min: 0.1 mL)
Room temperature specimens. Plasma, CSF, or other body fluids. Contaminated, heat-inactivated, hemolyzed , severely icteric, or lipemic specimens.
After separation from cells: Ambient: Unacceptable; Refrigerated: 2 weeks; Frozen: 1 year
|Asialo-GM1 Antibodies, IgG/IgM||
|GM1 Antibodies, IgG/IgM||
|GM2 Antibodies, IgG/IgM||
|GD1a Antibodies, IgG/IgM||
|GD1b Antibodies, IgG/IgM||
|GQ1b Antibodies, IgG/IgM||
Ganglioside antibodies are associated with diverse peripheral neuropathies. Elevated antibody levels to ganglioside-monosialic acid (GM1) and the neutral glycolipid, asialo-GM1 are associated with motor or sensorimotor neuropathies, particularly multifocal motor neuropathy. Anti-GM1 may occur as IgM (polyclonal or monoclonal) or IgG antibodies. These antibodies may also be found in patients with diverse connective tissue diseases as well as normal individuals. GD1a antibodies are associated with different variants of Guillain-Barre syndrome (GBS) particularly acute motor axonal neuropathy while GD1b antibodies are predominantly found in sensory ataxic neuropathy syndrome. Anti-GQ1b antibodies are seen in more than 80% of patients with Miller-Fisher syndrome and may be elevated in GBS patients with ophthalmoplegia. The role of isolated anti-GM2 antibodies is unknown. These tests by themselves are not diagnostic and should be used in conjunction with other clinical parameters to confirm disease.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
|Component Test Code*||Component Chart Name||LOINC|
|0051034||Asialo-GM1 Antibodies, IgG/IgM||88723-2|
|0051035||GM1 Antibodies, IgG/IgM||31500-2|
|0051036||GM2 Antibodies, IgG/IgM||88731-5|
|0051037||GD1a Antibodies, IgG/IgM||88724-0|
|0051038||GD1b Antibodies, IgG/IgM||88730-7|
|0051039||GQ1b Antibodies, IgG/IgM||88729-9|
- Anti-GM Antibodies
- Asialo-GM1 Antibodies, IgG/IgM
- Asialo-GM1, GM1, GD1b, GQ1b IgG and IgM
- Ganglioside Antibodies
- Ganglioside Abs IgG and IgM
- GM1, GM2, GD1a, GD1b, GQ1b IgG/IgM