Ordering Recommendation

Recommended reflex panel to diagnose and subclassify suspected von Willebrand disease.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Lt. blue (sodium citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.

Specimen Preparation

Transfer 3 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 1.5 mL)

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Serum. Clotted. Non-frozen or hemolyzed specimens.


Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20°C: 3 months; Frozen at -70°C: 6 months


Electrophoresis/Clotting/Microlatex Particle-Mediated Immunoassay/Platelet Agglutination




1-11 days

Reference Interval

Test Number
Reference Interval
  Factor VIII, Activity
Reference Interval (%)
0-6 years 56-191
7-9 years 76-199
10-11 years 80-209
12-13 years 72-198
14-15 years 69-237
16-17 years 63-221
18 years and older 56-191

  von Willebrand Factor, Activity (RCF)
Reference Interval (%)
0-6 years 51-215
7-9 years 52-176
10-11 years 60-195
12-13 years 50-184
14-15 years 50-203
16-17 years 49-204
18 years and older 51-215

  von Willebrand Factor, Antigen
Reference Interval (%)
0-6 years 52-214
7-9 years 62-180
10-11 years 63-189
12-13 years 60-189
14-15 years 57-199
16-17 years 50-205
18 years and older 52-214

Interpretive Data

Compliance Category



If von Willebrand ristocetin cofactor (RCF) or von Willebrand factor antigen (vWF Ag) or Factor VIII is low, von Willebrand Multimeric Analysis testing will be added.  If the ratio of RCF/vWF Ag is less than 0.7, vW Multimeric Analysis testing will be added.

Hotline History


CPT Codes

85240; 85246; 85245; if reflexed, add 85247


Component Test Code* Component Chart Name LOINC
0030095 Factor VIII, Activity 3209-4
0030250 von Willebrand Factor, Activity (RCF) 6014-5
0030285 von Willebrand Factor, Antigen 27816-8
2003388 von Willebrand Factor, RCF/Ag Ratio 81643-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Coag
  • von Willebrand Profile
von Willebrand Panel with Reflex to von Willebrand Multimeric Analysis