Ordering Recommendation

Recommended reflex panel to diagnose and subclassify suspected von Willebrand disease.




Electrophoresis/Clotting/Microlatex Particle-Mediated Immunoassay/Platelet Agglutination




1-11 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Lt. blue (sodium citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.

Specimen Preparation

Transfer 3 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 1.5 mL)

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Serum. Clotted. Non-frozen or hemolyzed specimens.


Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20°C: 3 months; Frozen at -70°C: 6 months

Reference Interval

Available Separately
Reference Interval
0092281 von Willebrand Factor Multimers By report
0030095 Factor VIII, Activity
Age Reference Interval
0-6 years 56-191%
7-9 years 76-199%
10-11 years 80-209%
12-13 years 72-198%
14-15 years 69-237%
16-17 years 63-221%
18 years and older 56-191%

0030285 von Willebrand Factor Antigen
Age Reference Interval
0-6 years 52-214%
7-9 years 62-180%
10-11 years 63-189%
12-13 years 60-189%
14-15 years 57-199%
16-17 years 50-205%
18 years and older 52-214%

0030250 von Willebrand Factor Activity (Ristocetin Cofactor)
Age Reference Interval
0-6 years 51-215%
7-9 years 52-176%
10-11 years 60-195%
12-13 years 50-184%
14-15 years 50-203%
16-17 years 49-204%
18 years and older 51-215%

Interpretive Data

Compliance Category



If von Willebrand ristocetin cofactor (RCF) or von Willebrand factor antigen (vWF Ag) or Factor VIII is low, von Willebrand Multimeric Analysis testing will be added.  If the ratio of RCF/vWF Ag is less than 0.7, vW Multimeric Analysis testing will be added.

Hotline History


CPT Codes

85240; 85246; 85245; if reflexed, add 85247


Component Test Code* Component Chart Name LOINC
0030095 Factor VIII, Activity 3209-4
0030250 von Willebrand Factor, Activity (RCF) 6014-5
0030285 von Willebrand Factor, Antigen 27816-8
2003388 von Willebrand Factor, RCF/Ag Ratio 81643-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Coag
  • von Willebrand Profile
von Willebrand Panel with Reflex to von Willebrand Multimeric Analysis