Ordering Recommendation

Acceptable panel to detect and subtype protein C and S deficiencies. Do not order if the individual has been on warfarin therapy in the previous 2-4 weeks.

Mnemonic
PROT C/S R
Methodology

Electromagnetic Mechanical Clot Detection/Enzyme-Linked Immunosorbent Assay/Microlatex Particle-Mediated Immunoassay

Performed

Mon-Fri

Reported

1-5 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Lt. blue (sodium citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.

Specimen Preparation

Transfer 4 mL platelet-poor plasma to an ARUP Standard Transport Tube. (Min: 2 mL)

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Serum. EDTA plasma, clotted or hemolyzed specimens.

Remarks
Stability

Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20°C: 3 months, at -70°C: 6 months

Reference Interval
Available Separately
Components
Reference Interval
0030113 Protein C, Functional Effective November 17, 2014
Age Reference Interval
1-4 days 17-53%
5-29 days 20-64%
30-89 days 21-65%
90-179 days 28-80%
180-364 days 37-81%
1-6 years 40-92%
7-9 years 70-142%
10-11 years 68-143%
12-13 years 66-162%
14-15 years 69-170%
16-17 years 70-171%
18 years and older 83-168%

0030111 Protein C, Total Antigen 1-4 days: 17-53%
5-29 days: 20-64%
30-89 days: 21-65%
90-179 days: 28-80%
180-364 days: 37-81%
1-5 years: 40-92%
6-10 years: 45-93%
11 years and older: 63-153%
0098894 Protein S Free, Antigen
Age Male Female
1-89 days 15-55% 15-55%
90-179 days 35-92% 35-92%
180-364 days 45-115% 45-115%
1-5 years 62-120% 62-120%
6-9 years 62-130% 62-130%
10-17 years 60-140% 60-140%
18 years and older 74-147% 55-123%

0030112 Protein S, Total Antigen
Age Male Female
1-4 days 12-60% 12-60%
5-29 days 22-78% 22-78%
30-89 days 33-93% 33-93%
90-179 days 54-118% 54-118%
180-364 days 55-119% 55-119%
1-5 years 54-118% 54-118%
6-10 years 41-114% 41-114%
11 years and older 84-134% 63-126%

Interpretive Data

Refer to report.

Compliance Category

FDA

Note

If Protein C Functional is low, Protein C, Total Antigen will be added. If Protein S Free is low, Protein S Total Antigen will be added. Additional charges apply.

Hotline History
N/A
CPT Codes

85303; 85306; if reflexed add 85302; if reflexed, add 85305

Components
Component Test Code* Component Chart Name LOINC
0030113 Protein C Functional 27819-2
0098894 Protein S Ag Free 27821-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Protein C, Functional and Protein S Free
Protein C, Functional with Reflex to Protein C, Total and Protein S, Free with Reflex to Protein S, Total