Antiphospholipid Syndrome Reflexive Panel
Ordering Recommendation
Preferred initial panel when antiphospholipid syndrome (APS) is strongly suspected.
Methodology
Electromagnetic Mechanical Clot Detection/Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed
Sun-Sat
Reported
1-2 days
New York DOH Approval Status
Specimen Required
Light Blue (Sodium Citrate) AND Serum Separator Tube (SST). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.
Transport 2 mL platelet poor plasma in an ARUP Standard Transport Tube. (Min: 2 mL)
AND Transport 1 mL serum in an ARUP Standard Transport Tube. (Min: 0.6 mL)
Plasma: CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.
Serum: Frozen.
For Lupus Anticoagulant Reflexive Panel (Plasma): Serum. EDTA plasma, clotted or hemolyzed specimens.
For cardiolipin and beta-2 glycoprotein antibodies (Serum): Plasma and other body fluids, heat-inactivated, hemolyzed, lipemic, or contaminated specimens.
Plasma: Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20°C or below: 3 months; Frozen at -70°C or below: 18 months
Serum: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Reference Interval
Test Number |
Components |
Reference Interval |
---|---|---|
Hexagonal Phospholipid Neutral Reflex | Negative | |
PTT-D Heparin Neutralized | 32-48 seconds | |
Platelet Neutralization (PTT-D, Confirm) | Negative | |
dRVVT Confirmation | Negative | |
PTT-LA Screen (PTT-D) | 32-48 seconds | |
Prothrombin Time | 12.0-15.5 seconds | |
Thrombin Time | 14.7-19.5 seconds | |
Reptilase Time | Less than 22.0 seconds | |
PTT-D 1:1 Mix | 32-48 seconds | |
dRVVT Screen | 33-44 seconds | |
dRVVT 1:1 Mix | 33-44 seconds | |
B2Glycoprotein 1, IgG Antibody | <=20 SGU | |
B2Glycoprotein 1, IgM Antibody | <=20 SMU | |
Cardiolipin Antibody IgG | 14 GPL or less | |
Cardiolipin Antibody IgM | 12 MPL or less |
Interpretive Data
See individual components.
FDA
Note
If PTT and dRVVT are normal, then no further testing is performed. If PTT is abnormal, Thrombin Time is added. If Thrombin Time is normal, PTT 1:1 mix is added. If Thrombin time is abnormal, Reptilase Time and PTT Heparin Neutralization are added. If PTT Heparin Neutralization is abnormal, PTT 1:1 mix is added. If PTT 1:1 mix is abnormal, Platelet Neutralization procedure is added. If dRVVT is abnormal, dRVVT 1:1 mix is added. If dRVVT 1:1 mix is abnormal, dRVVT confirmation is added. If Platelet Neutralization procedure and dRVVT confirmation are normal or if one is normal and the other not done, Hexagonal Phospholipid Neutralization is added. Additional charges apply.
Hotline History
Hotline History
CPT Codes
86147 x2; 86146 x2; 85610; 85730; 85613; if reflexed, additional CPT codes may apply: 85670; 85635; 85730; 85525; 85732; 85597; 85613 x2; 85598.
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0030079 | Lupus Anticoagulant Interpretation | 75882-1 |
0030082 | Hexagonal Phospholipid Neutral Reflex | 33930-9 |
0030084 | PTT-D Heparin Neutralized | 52123-7 |
0030184 | Platelet Neutralization (PTT-D, Confirm) | 75881-3 |
0030189 | dRVVT Confirmation | 50410-0 |
0030232 | PTT-LA Screen (PTT-D) | 34571-0 |
0030246 | Prothrombin Time | 5902-2 |
0030270 | Thrombin Time | 3243-3 |
0030296 | Reptilase Time | 6683-7 |
0030323 | PTT-D 1:1 Mix | 5946-9 |
0030352 | dRVVT Screen | 6303-2 |
0030353 | dRVVT 1:1 Mix | 75513-2 |
0050322 | B2Glycoprotein 1, IgG Antibody | 44448-9 |
0050323 | B2Glycoprotein 1, IgM Antibody | 44449-7 |
0050901 | Cardiolipin Antibody IgG | 3181-5 |
0050902 | Cardiolipin Antibody IgM | 3182-3 |
Aliases
- ACA
- aCL antibody
- Anti-Phospholipid Syndrome Reflexive Panel (Antiphospholipid Syndrome Reflexive Panel)
- APS panel
- APS Reflexive Panel
- B2Glycoprotein I
- B2GPI
- Cardiolipin Antibody
- dRVVT Screen
- Hexagonal Phospholipid Neutral Reflex
- Hughes Syndrome Panel
- Hypercoag
- Hypercoagulable
- Lupus Anticoagulant (LA)
- Platelet Neutralization
- Prothrombin Time
- PTT-D Heparin Neutralized
- Reptilase Time
- Thrombin Time