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Antiphospholipid Syndrome Reflex Panel
Ordering Recommendation
Preferred initial panel when antiphospholipid syndrome (APS) is strongly suspected.
New York DOH Approval Status
Specimen Required
Light blue (sodium citrate) AND serum separator tube (SST). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.
Transport 2 mL platelet poor plasma in an ARUP standard transport tube. (Min: 2 mL)
AND transport 1 mL serum in an ARUP standard transport tube. (Min: 0.6 mL)
Plasma: CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.
Serum: Frozen.
For Lupus Anticoagulant Reflexive Panel (Plasma): Serum. EDTA plasma, clotted or hemolyzed specimens.
For cardiolipin and beta-2 glycoprotein antibodies (serum): Plasma and other body fluids, heat-inactivated, hemolyzed, lipemic, or contaminated specimens.
Plasma: Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20 C or below: 3 months
Serum: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Methodology
Electromagnetic Mechanical Clot Detection/Chromogenic Assay/Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)
Performed
Sun-Sat
Reported
1-3 days
Reference Interval
Interpretive Data
See individual components.
Modified FDA
Note
Testing will include Beta-2 Glycoprotein 1 Antibodies, IgG and IgM (0050321); Cardiolipin Antibodies, IgG and IgM (0099344); and Lupus Anticoagulant Reflex Panel (3017009).
For the Lupus Anticoagulant Reflex Panel (3017009) portion of the panel, if PTT-LA Ratio and dRVVT Screen Ratio are normal, then no further clot-based testing is performed. If either the PTT-LA Ratio or dRVVT Screen Ratio are elevated, then Anti-Xa Qualitative Interpretation is added. If PTT-LA Ratio is elevated, then Thrombin Time is also added. If Anti-Xa Qualitative Interpretation is Present and Thrombin Time is greater than 30 seconds, then Hepzyme treatment is added. If PTT-LA Ratio is normal and Anti-Xa Qualitative Interpretation is Present, or Thrombin Time is greater than 30 seconds, and Anti-Xa Qualitative Interpretation is Not Present, or Thrombin Time is less than 30 seconds, and Anti-Xa Qualitative Interpretation is Present, then DOAC-Stop treatment is added. If either Hepzyme or DOAC-Stop treatment is added, then Neutralized PTT-LA Ratio and/or Neutralized dRVVT Screen Ratio are added. If dRVVT Screen Ratio is elevated in the absence of Hepzyme or DOAC-Stop, or if Neutralized dRVVT Screen Ratio is elevated, then dRVVT 1:1 Mix Ratio and dRVVT Confirmation Ratio are added. If PTT-LA Ratio is elevated in the absence of Hepzyme or DOAC-Stop treatment, or if Neutralized PTT-LA Ratio is elevated, then Hexagonal Phospholipid Confirmation is added. Additional charges apply.
Hotline History
Hotline History
CPT Codes
85610; 85613; 85730; 86147x2; 86146x2; if reflexed, additional CPT codes may apply: 85520; 85525; 85598; 85613; 85670; 85730.
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 3017163 | Testing Summary | 75882-1 |
Aliases
- ACA
- aCL antibody
- Anti-Phospholipid Syndrome Reflexive Panel (Antiphospholipid Syndrome Reflexive Panel)
- APS panel
- APS Reflexive Panel
- B2Glycoprotein I
- B2GPI
- Cardiolipin Antibody
- dRVVT Screen
- Hexagonal Phospholipid Neutral Reflex
- Hughes Syndrome Panel
- Hypercoag
- Hypercoagulable
- Lupus Anticoagulant (LA)
- Platelet Neutralization
- Prothrombin Time
- PTT-D Heparin Neutralized
- Thrombin Time
