Ordering Recommendation

Aids in evaluation of neuromyelitis optica (NMO) and NMO spectrum disorders.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Serum Separator Tube.

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Amniotic fluid, ocular fluid peritoneal fluid, synovial fluid, or plasma. Contaminated, hemolyzed, icteric, or lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 72 hours; Refrigerated: 2 weeks; Frozen: 1 month (avoid repeated freeze/thaw cycles)

Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Tue, Thu

Reported

1-6 days

Reference Interval

Test Number
Components
Reference Interval
  Aquaporin-4 Receptor Antibody 2.9 U/mL or less

Interpretive Data

Approximately 75 percent of patients with neuromyelitis optica (NMO) express antibodies to the aquaporin-4 (AQP4) receptor.  Diagnosis of NMO requires the presence of longitudinally extensive acute myelitis (lesions extending over 3 or more vertebral segments) and optic neuritis.  While absence of antibodies to the AQP4 receptor does not rule out the diagnosis of NMO, presence of this antibody is diagnostic for NMO.


Component
Interpretation
Aquaporin-4 Receptor Antibody Negative:  2.9 U/mL or less
Positive:    3.0 U/mL or greater

Compliance Category

FDA

Note

Hotline History

N/A

CPT Codes

86051

Components

Component Test Code* Component Chart Name LOINC
2003121 Aquaporin-4 Receptor Antibody 68548-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • AQP
  • AQP4
  • AQP4 antibody
  • AQP4 ELISA
  • Aquaporin
  • Devic's Ab
  • Devic's Antibody
  • Neuromyelitis Optica (NMO) Antibody
  • Neuromyelitis Optica IgG
  • NMO-IgG
  • Optic Neuritix Ab
  • Optic Neuritix Antibody
  • Optic-Spinal MS Antibody
  • Soft-NMOS
  • Transverse Myelitis Ab
  • Vision Loss Ab
Aquaporin-4 Receptor Antibody