Ordering Recommendation

Aids in evaluation of neuromyelitis optica (NMO) and NMO spectrum disorders.

Mnemonic
AQP4
Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Tue, Thu

Reported

1-6 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Serum Separator Tube.

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Amniotic fluid, ocular fluid peritoneal fluid, synovial fluid, or plasma. Contaminated, hemolyzed, icteric, or lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 72 hours; Refrigerated: 2 weeks; Frozen: 1 month (avoid repeated freeze/thaw cycles)

Reference Interval

Effective October 3, 2016

Negative 2.9 U/mL or less
Positive 3.0 U/mL or greater

Interpretive Data

Approximately 75 percent of patients with neuromyelitis optica (NMO) express antibodies to the aquaporin-4 (AQP4) receptor.  Diagnosis of NMO requires the presence of longitudinally extensive acute myelitis (lesions extending over 3 or more vertebral segments) and optic neuritis.  While absence of antibodies to the AQP4 receptor does not rule out the diagnosis of NMO, presence of this antibody is diagnostic for NMO.

No compliance statements are in use for this test.

Note
Hotline History
N/A
CPT Codes

83516

Components
Component Test Code* Component Chart Name LOINC
2003121 Aquaporin-4 Receptor Antibody 61430-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • AQP
  • AQP4
  • AQP4 antibody
  • AQP4 ELISA
  • Aquaporin
  • Devic's Ab
  • Devic's Antibody
  • Neuromyelitis Optica (NMO) Antibody
  • Neuromyelitis Optica IgG
  • NMO-IgG
  • Optic Neuritix Ab
  • Optic Neuritix Antibody
  • Optic-Spinal MS Antibody
  • Soft-NMOS
  • Transverse Myelitis Ab
  • Vision Loss Ab
Aquaporin-4 Receptor Antibody