When antiphospholipid syndrome (APS) is strongly suspected, preferred panel is Beta-2 Glycoprotein 1 Antibodies, IgG and IgM (0050321).
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
New York DOH Approval Status
Serum separator tube.
Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)
Plasma or other body fluids. Contaminated, hemolyzed, grossly icteric, or severely lipemic specimens.
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
|Test Number||Components||Reference Interval|
|Beta-2 Glycoprotein 1 Antibody, IgG||0-20 SGU|
|Beta-2 Glycoprotein 1 Antibody, IgM||0-20 SMU|
|Beta-2 Glycoprotein 1 Antibody, IgA||0-20 SAU|
The persistent presence of IgG and/or IgM beta 2 glycoprotein I (B2GPI) antibodies (greater than 99th percentile) is a laboratory criterion for the diagnosis of antiphospholipid syndrome (APS). Persistence is defined as moderate or high levels of IgG and/or IgM B2GPI antibodies detected in two or more specimens drawn at least 12 weeks apart (J Throm Haemost. 2006;4:295-306). B2GPI results greater than 20 SGU (IgG) and/or SMU (IgM) are considered positive based on the cutoff values established for this test. International reference materials and consensus units for anti-B2GPI antibodies have not been established (Clin Chim Acta. 2012;413(1-2):358-60; Arthritis Rheum. 2012;64(1):1-10.). Strong clinical correlation is recommended for a diagnosis of APS. Low positive IgG and IgM B2GPI antibody levels should be interpreted in light of APS-specific clinical manifestations and/or other criteria phospholipid antibody tests.
|Component Test Code*||Component Chart Name||LOINC|
|0050322||B2Glycoprotein 1, IgG Antibody||44448-9|
|0050323||B2Glycoprotein 1, IgM Antibody||44449-7|
|0050324||B2Glycoprotein 1, IgA Antibody||21108-6|
- Anti-B2-Glycoprotein 1
- Anti-B2-Glycoprotein I
- Anti-B2-GP 1
- Anti-B2-GP I
- Anti-beta-2 glycoprotein 1
- Anti-Beta-2-Glycoprotein I
- Apolipoprotein H
- B2-glycoprotein 1 antibodies
- B2GP Antibodies
- B2GPI IgG, IgM, IgA
- Beta 2 GP1 Ab IgA
- Beta 2 GP1 Ab IgG
- Beta 2 GP1 Ab IgM
- Beta 2GP1 Ab
- Beta-2 Glycoprotein 1