Ordering Recommendation

Not recommended as a stand-alone test. The preferred test for HCV screening and diagnosis is Hepatitis C Virus Antibody by CIA with Reflex to HCV by Quantitative NAAT (2010784). If the patient is immunocompromised or if acute HCV infection is suspected, the recommended test is Hepatitis C Virus (HCV) by Quantitative NAAT (3000572).

Mnemonic

HCV AB

Methodology

Qualitative Chemiluminescent Immunoassay

Performed

Sun-Sat

Reported

Within 24 hours

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Serum Separator Tube (SST). Also acceptable: Lavender (EDTA) or Pink (K2EDTA).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Specimens containing particulate material. Severely hemolyzed, heat-inactivated, or lipemic specimens. Heparinized plasma.

Remarks
Stability

After separation from cells: Ambient: Unacceptable; Refrigerated: 1 week; Frozen: Indefinitely (avoid freeze/thaw cycles)

Reference Interval

Negative

Interpretive Data

This assay should not be used for blood donor screening, associated re-entry protocols, or for screening Human Cell, Tissues and Cellular and Tissue-Based Products (HCT/P).


Hepatitis C Antibody by CIA Index
Negative 0.79 IV or less
Equivocal 0.80 to 0.99 IV
Low Positive 1.00 to 10.99 IV
High Positive 11.00 IV or greater
Index Value (IV) = Anti-HCV signal to cutoff (S/C)

Compliance Category

FDA

Note

For both low-positive and high-positive anti-HCV screening results, ARUP recommends collecting a new specimen and testing for Hepatitis C RNA by PCR to rule out active infection.

Hotline History

N/A

CPT Codes

86803

Components

Component Test Code* Component Chart Name LOINC
0020099 Hepatitis C Antibody by CIA Interp 13955-0
2002404 Hepatitis C Antibody by CIA Index 57006-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Anti-HCV
  • HCV Ab
  • HCV Antibody
  • HCVAB, Serum
  • Hepatitis C Viral Antibody, Serum
  • non-A, non-B Hepatitis
Hepatitis C Virus Antibody by CIA