Ordering Recommendation

Monitor patients receiving creatine supplementation. May be useful when evaluating for possible creatine transporter deficiency; however, the preferred test is Creatine Disorders Panel, Urine (2002333).


Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)




2-9 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

Random Urine or 24 Hour Urine, refrigerate during collection.

Specimen Preparation

Transfer 2 mL aliquot from a well-mixed random collection or 24 hour urine to an ARUP Standard Transport Tube and freeze immediately. (Min: 0.5 mL)

Storage/Transport Temperature


Unacceptable Conditions

24 Hour Urine: Submit with order time of collection, and volume.


Ambient: 6 hours; Refrigerated: 24 hours; Frozen: 6 months (Three freeze/thaw cycles are acceptable.)

Reference Interval

Effective May 20, 2013

Age Reference Interval
Less than 4 years 23 - 1500 mmol/mol creatinine
4-10 years 24 - 890 mmol/mol creatinine
11-150  years 10 - 370 mmol/mol creatinine

Interpretive Data

For random or timed specimens other than 24 hrs, the result represents the total milligrams of creatine excreted during the collection period.

Reference ranges for creatine have been established for random urine collections, in mmol/mol creatinine.

Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.


To evaluate inherited disorders of creatine metabolism or transport, please use Creatine Disorders Panel, Plasma or Serum (2002328) and/or Creatine Disorders Panel, Urine (2002333).

Hotline History
CPT Codes


Component Test Code* Component Chart Name LOINC
0097110 Total Volume 19153-6
0097111 Hours Collected 30211-7
2002334 Creatinine, Urine 14683-7
2002338 Creatine, Urine 34275-8
2002344 Creatine, Urine - mg/24hr 2150-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
  • Urine creatine
Creatine, Urine