2002028
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Virilization Panel 1

VIRIL PANEL
Example Reports
High
Normal

Ordering Recommendation

Aids in the detection and subclassification of hyperandrogenism. Most useful in cisgender females and children with moderate/severe hirsutism or hirsutism of any degree when it is sudden in onset or rapidly progressive. Hirsutism Evaluation Panel (2001763) is generally preferred.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube or green (sodium or lithium heparin). Collect between 6-10 a.m. Also acceptable: Lavender (EDTA).

Specimen Preparation

Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions
Remarks
Stability

Ambient: 2 hours; Refrigerated: 1 week; Frozen: 6 months

Methodology

Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry

Performed

Sun-Sat

Reported

1-5 days

Reference Interval

Test Number
 Components
 Reference Interval
  Testosterone by Mass Spec
Age
 Male (ng/dL)
 Female (ng/dL)
Premature (26-28 weeks) 59-125 5-16
Premature (31-35 weeks) 37-198 5-22
Newborn 75-400 20-64
1-5 months 14-363 Less than 20
6-24 months Less than 37 Less than 9
2-3 years Less than 15 Less than 20
4-5 years Less than 19 Less than 30
6-7 years Less than 13 Less than 7
8-9 years 2-8 1-11
10-11 years 2-165 3-32
12-13 years 3-619 6-50
14-15 years 31-733 6-52
16-17 years 158-826 9-58
18-39 years 300-1080 9-55
40-59 years 300-890 9-55
60 years and older 300-720 5-32
Premenopausal (18 years and older) Not Applicable 9-55
Postmenopausal Not Applicable 5-32
Tanner Stage I 2-15 2-17
Tanner Stage II 3-303 5-40
Tanner Stage III 10-851 10-63
Tanner Stage IV-V 162-847 11-62

  Androstenedione by TMS
Age
 Male (ng/mL)
 Female (ng/mL)
Premature Infants (26-28 weeks Day 4) 0.92-2.82 0.92-2.82
Premature Infants (31-35 weeks Day 4) 0.80-4.46 0.80-4.46
Full Term Infants (1-7 days) 0.20-2.90 0.20-2.90
8-30 days 0.18-0.80 0.18-0.80
1-5 months 0.06-0.68 0.06-0.68
6-24 months 0.03-0.15 Less than 0.15
2-3 years Less than 0.11 Less than 0.16
4-5 years 0.02-0.17 0.02-0.21
6-7 years 0.01-0.29 0.02-0.28
8-9 years 0.03-0.30 0.04-0.42
10-11 years 0.07-0.39 0.09-1.23
12-13 years 0.10-0.64 0.24-1.73
14-15 years 0.18-0.94 0.39-2.00
16-17 years 0.30-1.13 0.35-2.12
18-39 years 0.33-1.34 0.26-2.14
40 years and older 0.23-0.89 0.13-0.82
Premenopausal Not Applicable 0.26-2.14
Postmenopausal Not Applicable 0.13-0.82
Tanner Stage I 0.04-0.32 0.05-0.51
Tanner Stage II 0.08-0.48 0.15-1.37
Tanner Stage III 0.14-0.87 0.37-2.24
Tanner Stage IV-V 0.27-1.07 0.35-2.05

  Dehydroepiandrosterone by TMS
Age Male (ng/mL) Female (ng/mL)
Premature Less than 40 Less than 40
0-1 days Less than 11 Less than 11
2-6 days Less than 8.7 Less than 8.7
7 days-1 month Less than 5.8 Less than 5.8
1-5 months Less than 2.9 Less than 2.9
6-24 months Less than 2.5 Less than 1.99
2-3 years Less than 0.63 Less than 0.85
4-5 years Less than 0.95 Less than 1.03
6-7 years 0.06-1.93 Less than 1.79
8-9 years 0.10-2.08 0.14-2.35
10-11 years 0.32-3.08 0.43-3.78
12-13 years 0.57-4.10 0.89-6.21
14-15 years 0.93-6.04 1.22-7.01
16-17 years 1.17-6.52 1.42-9.00
18-39 years 1.33-7.78 1.33-7.78
40 years and older 0.63-4.70 0.63-4.70
Postmenopausal Not Applicable 0.60-5.73
Tanner Stage I 0.11-2.37 0.14-2.76
Tanner Stage II 0.37-3.66 0.83-4.87
Tanner Stage III 0.75-5.24 1.08-7.56
Tanner Stage IV-V 1.22-6.73 1.24-7.88

Interpretive Data

Free or bioavailable testosterone measurements may provide supportive information.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)

Note

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
02/20/2024
X
N/A

CPT Codes

82157; 82626; 84403

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Components

Component Test Code* Component Chart Name LOINC
0081058 Testosterone by Mass Spec 2986-8
2001639 Androstenedione by TMS 1854-9
2001641 Dehydroepiandrosterone by TMS 2193-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Dehydroepiandrosterone (Virilization Panel 1)
  • Androstenedione (Virilization Panel 1)
  • Testosterone (Virilization Panel 1)
Virilization Panel 1