Ordering Recommendation

Aids in the detection and subclassification of hyperandrogenism. Most useful in women and children with moderate/severe hirsutism or hirsutism of any degree when it is sudden in onset or rapidly progressive.

Mnemonic

HIRSUTISM

Methodology

Quantitative Chemiluminescent Immunoassay/Electrochemiluminescent Immunoassay/Liquid Chromatography-Tandem Mass Spectrometry

Performed

Sun, Tue-Fri

Reported

1-4 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Collect between 6-10 a.m.

Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 2.5 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 1.5 mL)

Storage/Transport Temperature

Frozen.

Unacceptable Conditions

Hemolyzed specimens.

Remarks
Stability

After separation from cells: Ambient: 2 hours; Refrigerated: 48 hours; Frozen: 2 months

Reference Interval

Test Number
Components
Reference Interval
  DHEAS
Age Male (ug/dL) Female (ug/dL)
0-6 days 108-607 108-607
7-30 days 32-431 32-431
1-5 months 3-124 3-124
6-35 months 0-33 0-29
3-6 years 0-44 0-47
7-9 years 5-115 5-94
10-14 years 22-332 22-255
15-19 years 88-483 63-373
20-24 years 211-492 148-407
25-34 years 160-449 99-340
35-44 years 89-427 61-337
45-54 years 44-331 35-256
55-64 years 52-295 19-205
65-74 years 34-249 9-246
75 years and older 16-123 12-154
Tanner Stage I 7-209 7-126
Tanner Stage II 28-260 13-241
Tanner Stage III 39-390 32-446
Tanner Stage IV & V 81-488 65-371

  Testosterone by Mass Spec
Age
Male (ng/dL)
Female (ng/dL)
Premature (26-28 weeks) 59-125 5-16
Premature (31-35 weeks) 37-198 5-22
Newborn 75-400 20-64
1-5 months 14-363 Less than 20
6-24 months Less than 37 Less than 9
2-3 years Less than 15 Less than 20
4-5 years Less than 19 Less than 30
6-7 years Less than 13 Less than 7
8-9 years 2-8 1-11
10-11 years 2-165 3-32
12-13 years 3-619 6-50
14-15 years 31-733 6-52
16-17 years 158-826 9-58
18-39 years 300-1080 9-55
40-59 years 300-890 9-55
60 years and older 300-720 5-32
Premenopausal (18 years and older) Not Applicable 9-55
Postmenopausal Not Applicable 5-32
Tanner Stage I 2-15 2-17
Tanner Stage II 3-303 5-40
Tanner Stage III 10-851 10-63
Tanner Stage IV-V 162-847 11-62

  Testosterone, Free by Mass Spec
Age
Male (pg/mL)
Female (pg/mL)
1-6 years Less than 0.6 Less than 0.6
7-9 years 0.1-0.9 0.6-1.8
10-11 0.1-6.3 0.1-3.5
12-13 0.5-98.0 0.9-6.8
14-15 3-138.0 1.2-7.5
16-17 38.0-173.0 1.2-9.9
18 years and older 47-244 Not Applicable
18-30 Not Applicable 0.8-7.4
31-40 Not Applicable 1.3-9.2
41-51 Not Applicable 1.1-5.8
Postmenopausal Not Applicable 0.6-3.8
Tanner Stage I Less than or equal to 3.7 Less than 2.2
Tanner Stage II 0.3-21 0.4-4.5
Tanner Stage III 1.0-98.0 1.3-7.5
Tanner Stage IV 35.0-169.0 1.1-15.5
Tanner Stage V 41.0-239.0 0.8-9.2

  Sex Hormone Binding Globulin
Age
Male (nmol/L)
Female (nmol/L)
1-30 days 13-85 14-60
31-364 days 70-250 60-215
1-3 years 50-180 60-190
4-6 years 45-175 55-170
7-9 years 28-190 35-170
10-12 years 23-160 17-155
13-15 years 13-140 11-120
16-17 years 10-60 19-145
18-49 years 17-56 25-122
50 years and older 19-76 17-125
Tanner Stage I 26-186 30-173
Tanner Stage II 22-169 16-127
Tanner Stage III 13-104 12-98
Tanner Stage IV 11-60 14-151
Tanner Stage V 11-71 23-165

  Androstenedione by TMS
Age
Male (ng/mL)
Female (ng/mL)
Premature Infants (26-28 weeks Day 4) 0.92-2.82 0.92-2.82
Premature Infants (31-35 weeks Day 4) 0.80-4.46 0.80-4.46
Full Term Infants (1-7 days) 0.20-2.90 0.20-2.90
8-30 days 0.18-0.80 0.18-0.80
1-5 months 0.06-0.68 0.06-0.68
6-24 months 0.03-0.15 Less than 0.15
2-3 years Less than 0.11 Less than 0.16
4-5 years 0.02-0.17 0.02-0.21
6-7 years 0.01-0.29 0.02-0.28
8-9 years 0.03-0.30 0.04-0.42
10-11 years 0.07-0.39 0.09-1.23
12-13 years 0.10-0.64 0.24-1.73
14-15 years 0.18-0.94 0.39-2.00
16-17 years 0.30-1.13 0.35-2.12
18-39 years 0.33-1.34 0.26-2.14
40 years and older 0.23-0.89 0.13-0.82
Premenopausal Not Applicable 0.26-2.14
Postmenopausal Not Applicable 0.13-0.82
Tanner Stage I 0.04-0.32 0.05-0.51
Tanner Stage II 0.08-0.48 0.15-1.37
Tanner Stage III 0.14-0.87 0.37-2.24
Tanner Stage IV-V 0.27-1.07 0.35-2.05

Interpretive Data

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)

Note

Hotline History

N/A

CPT Codes

82157; 82627; 84403; 84270

Components

Component Test Code* Component Chart Name LOINC
0070040 DHEAS 2191-5
0081058 Testosterone by Mass Spec 2986-8
0081096 Testosterone, Free by Mass Spec 49042-5
0099375 Sex Hormone Binding Globulin 13967-5
2001639 Androstenedione by TMS 1854-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

Hirsutism Evaluation Panel