Ordering Recommendation

Aids in the detection and subclassification of hyperandrogenism. Most useful in women and children with moderate/severe hirsutism or hirsutism of any degree when it is sudden in onset or rapidly progressive.

Mnemonic

HIRSUTISM

Methodology

Quantitative Chemiluminescent Immunoassay/Electrochemiluminescent Immunoassay/Liquid Chromatography-Tandem Mass Spectrometry

Performed

Sun, Tue-Fri

Reported

1-4 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Collect between 6-10 a.m.

Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 2.5 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 1.5 mL)

Storage/Transport Temperature

Frozen.

Unacceptable Conditions

Hemolyzed specimens.

Remarks
Stability

After separation from cells: Ambient: 2 hours; Refrigerated: 48 hours; Frozen: 2 months

Reference Interval

Test Number
Components
Reference Interval
2001638 Androstenedione Effective August 19, 2013
Age Female Male
Premature Infants, 26-28 weeks-Day 4 0.92-2.82 ng/mL 0.92-2.82 ng/mL
Premature Infants, 31-35 weeks-Day 4 0.80-4.46 ng/mL 0.80-4.46 ng/mL
Full-term Infants, 1-7 days 0.20-2.90 ng/mL 0.20-2.90 ng/mL
8-30 days 0.18-0.80 ng/mL 0.18-0.80 ng/mL
1-5 months 0.06-0.68 ng/mL 0.06-0.68 ng/mL
6-24 months Less than 0.15 ng/mL 0.03-0.15 ng/mL
2-3 years Less than 0.16 ng/mL Less than 0.11 ng/mL
4-5 years 0.02-0.21 ng/mL 0.02-0.17 ng/mL
6-7 years 0.02-0.28 ng/mL 0.01-0.29 ng/mL
8-9 years 0.04-0.42 ng/mL 0.03-0.30 ng/mL
10-11 years 0.09-1.23 ng/mL 0.07-0.39 ng/mL
12-13 years 0.24-1.73 ng/mL 0.10-0.64 ng/mL
14-15 years 0.39-2.00 ng/mL 0.18-0.94 ng/mL
16-17 years 0.35-2.12 ng/mL 0.30-1.13 ng/mL
18-39 years 0.26-2.14 ng/mL 0.33-1.34 ng/mL
40 years and older 0.13-0.82 ng/mL 0.23-0.89 ng/mL
Pre-menopausal 0.26-2.14 ng/mL Does Not Apply
Postmenopausal 0.13-0.82 ng/mL Does Not Apply
Tanner Stage I 0.05-0.51 ng/mL 0.04-0.32 ng/mL
Tanner Stage II 0.15-1.37 ng/mL 0.08-0.48 ng/mL
Tanner Stage III 0.37-2.24 ng/mL 0.14-0.87 ng/mL
Tanner Stage IV-V 0.35-2.05 ng/mL 0.27-1.07 ng/mL

0070040 Dehydroepiandrosterone Sulfate, Serum
Age
Male
Female
0-6 days
7-30 days
1-5 months
6-35 months
3-6 years
7-9 years
10-14 years
15-19 years
20-24 years
25-34 years
35-44 years
45-54 years
55-64 years
65-74 years
75 years and older
108-607 µg/dL
32-431 µg/dL
3-124µg/dL
0-33 µg/dL
0-44 µg/dL
5-115 µg/dL
22-332 µg/dL
88-483 µg/dL
211-492 µg/dL
160-449 µg/dL
89-427 µg/dL
44-331µg/dL
52-295 µg/dL
34-249 µg/dL
16-123 µg/dL
108-607 µg/dL
32-431 µg/dL
3-124 µg/dL
0-29 µg/dL
0-47 µg/dL
5-94 µg/dL
22-255 µg/dL
63-373 µg/dL
148-407 µg/dL
99-340µg/dL
61-337 µg/dL
35-256 µg/dL
19-205 µg/dL
9-246 µg/dL
12-154 µg/dL
Tanner Stage I
Tanner Stage II
Tanner Stage III
Tanner Stage IV & V
7-209 µg/dL
28-260 µg/dL
39-390 µg/dL
81-488 µg/dL
7-126 µg/dL
13-241 µg/dL
32-446 µg/dL
65-371 µg/dL

0081059 Testosterone, Free (Adult Females, Children, or Individuals on Testosterone-Suppressing Hormone Therapy)
Female Free Testosterone, pg/mL
Male Free Testosterone, pg/mL
1-6 years: Less than 0.6 pg/mL
7-9 years: 0.6-1.8 pg/mL
10-11 years: 0.1-3.5 pg/mL
12-13 years: 0.9-6.8 pg/mL
14-15 years: 1.2-7.5 pg/mL
16-17 years: 1.2-9.9 pg/mL
18-30 years: 0.8-7.4 pg/mL
31-40 years: 1.3-9.2 pg/mL
41-51 years: 1.1-5.8 pg/mL
Postmenopausal: 0.6-3.8 pg/mL
Tanner Stage I: Less than 2.2 pg/mL
Tanner Stage II: 0.4-4.5 pg/mL
Tanner Stage III: 1.3-7.5 pg mL
Tanner Stage IV: 1.1-15.5 pg/mL
Tanner Stage V: 0.8-9.2 pg/mL
1-6 years: Less than 0.6 pg/mL
7-9 years: 0.1-0.9 pg/mL
10-11 years: 0.1-6.3 pg/mL
12-13 years: 0.5-98.0 pg/mL
14-15 years: 3-138.0 pg/mL
16-17 years: 38.0-173.0 pg/mL
18 years and older: 47-244 pg/mL
Tanner Stage I: Less than or equal to 3.7 pg/mL
Tanner Stage II: 0.3-21 pg/mL
Tanner Stage III: 1.0-98.0 pg mL
Tanner Stage IV: 35.0-169.0 pg/mL
Tanner Stage V: 41.0-239.0 pg/mL

0081058 Testosterone (Adult Females, Children, or Individuals on Testosterone-Suppressing Hormone Therapy) Effective August 19, 2013
Age
Female
Male
Premature (26-28 weeks) 5-16 ng/dL 59-125 ng/dL
Premature (31-35 weeks) 5-22 ng/dL 37-198 ng/dL
Newborn 20-64 ng/dL 75-400 ng/dL
1-5 months Less than 20 ng/dL 14-363 ng/dL
6-24 months Less than 9 ng/dL Less than 37 ng/dL
2-3 years Less than 20 ng/dL Less than 15 ng/dL
4-5 years Less than 30 ng/dL Less than 19 ng/dL
6-7 years Less than 7 ng/dL Less than 13 ng/dL
8-9 years 1-11ng/dL 2-8 ng/dL
10-11 years 3-32 ng/dL 2-165 ng/dL
12-13 years 6-50 ng/dL 3-619 ng/dL
14-15 years 6-52 ng/dL 31-733 ng/dL
16-17 years 9-58 ng/dL 158-826 ng/dL
18-39 years 9-55 ng/dL 300-1080 ng/dL
40-59 years 9-55 ng/dL 300-890 ng/dL
60 years and older 5-32 ng/dL 300-720 ng/dL
Premenopausal (18 years and older) 9-55 ng/dL Does Not Apply
Postmenopausal 5-32 ng/dL Does Not Apply
Tanner Stage I 2-17 ng/dL 2-15 ng/dL
Tanner Stage II 5-40 ng/dL 3-303 ng/dL
Tanner Stage III 10-63 ng/dL 10-851 ng/dL
Tanner Stage IV-V 11-62 ng/dL 162-847 ng/dL

0099375 Sex Hormone Binding Globulin
Age Male Female
1-30 days
31-364 days
1-3 years
4-6 years
7-9 years
10-12 years
13-15 years
16-17 years
18-49 years
50 years and older
13-85 nmol/L
70-250 nmol/L
50-180 nmol/L
45-175 nmol/L
28-190 nmol/L
23-160 nmol/L
13-140 nmol/L
10-60 nmol/L
17-56 nmol/L
19-76 nmol/L
14-60 nmol/L
60-215 nmol/L
60-190 nmol/L
55-170 nmol/L
35-170 nmol/L
17-155 nmol/L
11-120 nmol/L
19-145 nmol/L
25-122 nmol/L
17-125 nmol/L
Tanner Stage I
Tanner Stage II
Tanner Stage III
Tanner Stage IV
Tanner Stage V
26-186 nmol/L
22-169 nmol/L
13-104 nmol/L
11-60 nmol/L
11-71 nmol/L
30-173 nmol/L
16-127 nmol/L
12-98 nmol/L
14-151 nmol/L
23-165 nmol/L

Interpretive Data

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)

Note

Hotline History

N/A

CPT Codes

82157; 82627; 84403; 84270

Components

Component Test Code* Component Chart Name LOINC
0070040 DHEAS 2191-5
0081058 Testosterone by Mass Spec 2986-8
0081096 Testosterone, Free by Mass Spec 49042-5
0099375 Sex Hormone Binding Globulin 13967-5
2001639 Androstenedione by TMS 1854-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

Hirsutism Evaluation Panel