Aid in the diagnosis and prognostication of Crohn disease.
Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Serum separator tube (SST).
Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)
Plasma, other body fluids, grossly icteric, heat-inactivated, grossly hemolyzed, severely lipemic, or contaminated specimens.
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year
(avoid repeated freeze/thaw cycles)
|Saccharomyces cerevisiae Ab (gASCA), IgG||
|Laminaribioside Carbohydrate Ab ALCA IgG||
|Mannobioside Carbohydrate Ab (AMCA), IgG||
|Chitobioside Carbohydrate Ab (ACCA), IgA||
Anti-glycan serologic markers may serve as an aid in the diagnosis of Crohn disease (CD) and an indicator of disease prognosis. Anti-saccharomyces cerevisiae antibody (gASCA) has the highest diagnostic value and anti-chitobioside carbohydrate antibody (ACCA) has the highest association with more-aggressive disease. Both ACCA and gASCA are associated equally with the need for surgery. When found in combination, these markers have the best diagnostic potential. A combination of two or more of the four anti-glycan markers have a significant association with complications and the need for surgery than any single marker alone. A negative result does not rule out CD.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Analyte Specific Reagent (ASR)
86671; 83516 x3
|Component Test Code*||Component Chart Name||LOINC|
|2001609||Saccharomyces cerevisiae Ab (gASCA), IgG||47321-5|
|2001610||Mannobioside Carbohydrate Ab (AMCA), IgG||53597-1|
|2001611||Laminaribioside Carbohydrate Ab ALCA IgG||53596-3|
|2001612||Chitobioside Carbohydrate Ab (ACCA), IgA||53594-8|
|2013334||Crohn Disease Prognostic Pan Interp.||62364-5|
- Chitobioside Carbohydrate Antibody (ACCA), IgA
- Glycan Antibodies
- IBD Prognostic Panel
- Inflammatory Bowel Disease Prognostic Panel
- Laminaribioside Carbohydrate Antibody (ALCA), IgG
- Saccharomyces cerevisiae Antibody (gASCA), IgG