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Renin, Direct
Ordering Recommendation
New York DOH Approval Status
Specimen Required
Collect midmorning (i.e., 7am - 10am) after patient has been sitting, standing, or walking for at least 30 minutes and seated for 5-15 minutes. If the patient is supine, ensure that the patient is in this position for at least 30 minutes prior to collection. Fasting specimens are recommended but not required.
Lavender (EDTA) from a supine or upright patient.. Do not collect in refrigerated tubes nor store tubes on ice. Process blood at room temperature and centrifuge tubes in a non-refrigerated centrifuge.
Separate from cells ASAP or within 2 hours of collection. Transfer 2 mL plasma to an ARUP Standard Transport Tube and freeze immediately. (Min: 1 mL)
Frozen
Serum. Specimens collected in citrate, heparin, or oxalate. Grossly hemolyzed or refrigerated specimens.
Ambient: 8 hours; Refrigerated: Unacceptable; Frozen: 4 weeks
Methodology
Quantitative Chemiluminescent Immunoassay
Performed
Mon, Wed, Fri
Reported
1-5 days
Reference Interval
Upright ≤40 yr: 4.2-52.2 pg/mL
Upright >40 yr: 3.6-81.6 pg/mL
Supine ≤40 yr: 3.2-33.2 pg/mL
Supine >40 yr: 2.5-45.1 pg/mL
Interpretive Data
FDA
Note
Do not use this test for patients treated with Cathepsin B. Menstruating females and those taking estrogen-containing medications may have lower renin direct concentrations, resulting in falsely high aldosterone-renin ratio (ARR). In these cases, order Aldosterone/Renin Activity Ratio (ARUP Test code 0070073). Refer to the Additional Technical Information for Endocrine Society recommendations for patient preparation, specimen collection, medications for hypertension control during confirmatory testing for primary aldosteronism, and factors that may lead to false-positive or false-negative ARR results.
Hotline History
CPT Codes
84244
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 2001576 | Direct Renin | 35570-1 |
Aliases
- Direct Renin
