Ordering Recommendation

The combined aldosterone/renin tests are preferred when screening for hyperaldosteronism. Refer to Aldosterone/Renin Activity Ratio (0070073) or Aldosterone and Renin Direct, With Ratio (3005949).

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Collect midmorning (i.e., 7am - 10am) after patient has been sitting, standing, or walking for at least 30 minutes and seated for 5-15 minutes. If the patient is supine, ensure that the patient is in this position for at least 30 minutes prior to collection. Fasting specimens are recommended but not required.


Lavender (EDTA) from a supine or upright patient.. Do not collect in refrigerated tubes nor store tubes on ice. Process blood at room temperature and centrifuge tubes in a non-refrigerated centrifuge.

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 2 mL plasma to an ARUP Standard Transport Tube and freeze immediately. (Min: 1 mL)

Storage/Transport Temperature


Unacceptable Conditions

Serum. Specimens collected in citrate, heparin, or oxalate. Grossly hemolyzed or refrigerated specimens.


Ambient: 8 hours; Refrigerated: Unacceptable; Frozen: 4 weeks


Quantitative Chemiluminescent Immunoassay


Mon, Wed, Fri


1-5 days

Reference Interval

Upright ≤40 yr: 4.2-52.2 pg/mL
Upright >40 yr: 3.6-81.6 pg/mL
Supine ≤40 yr: 3.2-33.2 pg/mL
Supine >40 yr: 2.5-45.1 pg/mL

Interpretive Data

Compliance Category



Do not use this test for patients treated with Cathepsin B. Menstruating females and those taking estrogen-containing medications may have lower renin direct concentrations, resulting in falsely high aldosterone-renin ratio (ARR). In these cases, order Aldosterone/Renin Activity Ratio (ARUP Test code 0070073). Refer to the Additional Technical Information for Endocrine Society recommendations for patient preparation, specimen collection, medications for hypertension control during confirmatory testing for primary aldosteronism, and factors that may lead to false-positive or false-negative ARR results.

Hotline History


CPT Codes



Component Test Code* Component Chart Name LOINC
2001576 Direct Renin 35570-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Direct Renin
Renin, Direct