Renin, Direct

2001575
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Additional Technical Information

Ordering Recommendation

The combined aldosterone/renin tests are preferred when screening for hyperaldosteronism. Refer to Aldosterone/Renin Activity Ratio (0070073) or Aldosterone and Renin, Direct with Ratio (2002582).

Mnemonic

RENIND

Methodology

Quantitative Immunoradiometry

Performed

Mon

Reported

1-8 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Collect midmorning after patient has been sitting, standing, or walking for at least 2 hours and seated for 5-15 minutes. Refer to the Additional Technical Information for specific patient preparation recommendations.

Collect

Lavender (EDTA) or Pink (K2EDTA). Do not collect in refrigerated tubes.

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 2 mL plasma to an ARUP Standard Transport Tube and freeze immediately. (Min: 1 mL)

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Serum. Specimens collected in citrate, heparin, or oxalate. Hemolyzed specimens.

Remarks
Stability

Ambient: 4 hours; Refrigerated: Unacceptable; Frozen: 4 weeks

Reference Interval

2.5-45.7 pg/mL

Interpretive Data



Compliance Category

FDA

Note

Do not use this test for patients treated with Cathepsin B. Menstruating females and those taking estrogen-containing medications may have lower renin direct concentrations, resulting in falsely high aldosterone-renin ratio (ARR). In these cases, order Aldosterone/Renin Activity Ratio (ARUP Test code 0070073). Refer to the Additional Technical Information for Endocrine Society recommendations for patient preparation, specimen collection, medications for hypertension control during confirmatory testing for primary aldosteronism, and factors that may lead to false-positive or false-negative ARR results.

Hotline History

N/A

CPT Codes

84244

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Components

Component Test Code* Component Chart Name LOINC
2001576 Direct Renin 35570-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Direct Renin
Renin, Direct