Ordering Recommendation

Screen and diagnose hyperaldosteronism.

Mnemonic
A/RA
Methodology

Quantitative Chemiluminescent Immunoassay/Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Sun-Sat

Reported

1-5 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

Collect midmorning after patient has been sitting, standing, or walking for at least 2 hours, and seated for 5-15 minutes. Refer to the Additional Technical Information for specific patient preparation recommendations.

Collect

Serum Separator Tube (SST) AND Lavender (K2EDTA) or Pink (K2EDTA). Do not collect in refrigerated tubes.

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection.
Serum:
Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)
AND
 
Plasma:
Transfer 2 mL EDTA plasma to an ARUP Standard Transport Tube and freeze immediately. (Min: 1.2 mL)

Storage/Transport Temperature

Both specimens should be collected and submitted together for testing.
Serum:
Frozen.
Plasma: CRITICAL FROZEN.  Separate specimens must be submitted when additional tests are ordered.

Unacceptable Conditions

Plasma collected in citrate, heparin, or oxalate. Hemolyzed specimens.

Remarks
Stability

Serum: Ambient: 8 hours; Refrigerated: 5 days; Frozen: 1 month
Plasma: Ambient: 6 hours; Refrigerated: Unacceptable; Frozen: 1 month

Reference Interval
Test Number
Components
Reference Interval
0070015 Aldosterone, Serum Effective May 16, 2011
Age
Posture Unspecified
Supine
Upright
0-6 days 5.0-102.0 ng/dL
1-3 weeks 6.0-179.0 ng/dL
1-11 months 7.0-99.0 ng/dL
1-2 years 7.0-93.0 ng/dL
3-10 years 4.0-44.0 ng/dL
11-14 years 4.0-31.0 ng/dL
15 years and older Less than or equal to 31.0 ng/dL Less than or equal to 16.0 ng/dL 4.0-31.0 ng/dL

0070105 Renin Activity
Adult, normal sodium diet
Children, normal sodium diet, supine:
Children, normal sodium diet, upright:
Supine: 0.2-1.6 ng/mL/hr Newborn (1-7 days): 2.0-35.0 ng/mL/hr 0-3 years: Not Available
Upright: 0.5-4.0 ng/mL/hr Cord blood: 4.0-32.0 ng/mL/hr 4-5 years: Less than or equal to 15 ng/mL/hr
1-12 months: 2.4-37.0 ng/mL/hr 6-10 years: Less than or equal to 17 ng/mL/hr
13 months-3 years:1.7-11.2 ng/mL/hr 11-15 years: Less than or equal to 16 ng/mL/hr
4-5 years:1.0-6.5 ng/mL/hr
6-10 years: 0.5-5.9 ng/mL/hr
11-15 years: 0.5-3.3 ng/mL/hr

  Aldosterone/Renin Activity Calculation Effective May 16, 2011

Less than or equal to 25
An Aldosterone/Renin Activity Ratio of greater than 25 is suggestive of hyperaldosteronism if the aldosterone concentration is greater than 15 ng/dL.

Interpretive Data



Compliance Category

Laboratory Developed Test (LDT)

Note

Refer to the Additional Technical Information for Endocrine Society recommendations for patient preparation, specimen collection, medications for hypertension control during confirmatory testing for primary aldosteronism, and factors that may lead to false-positive or false-negative ARR results.

Hotline History
N/A
CPT Codes

82088; 84244

Components
Component Test Code* Component Chart Name LOINC
0070015 Aldosterone 1763-2
0070074 Aldosterone/Renin Activity Calculation 30894-0
0070105 Renin Activity 2915-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Aldosterone and Plasma Renin Activity
  • Aldosterone serum
  • Aldosterone/Renin Activity
  • ARR
  • ARR-P
  • PRA
  • Renin Activity
Aldosterone/Renin Activity Ratio