Ordering Recommendation

Useful as a biomarker of acute thallium exposure. For the assessment of chronic exposure, consider Thallium, Urine (0025019).

Mnemonic
THALB
Methodology

Quantitative Inductively Coupled Plasma-Mass Spectrometry

Performed

Sun-Sat

Reported

1-3 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and non-essential over-the-counter medications (upon the advice of their physician).

Collect

Royal Blue (K2EDTA or Na2EDTA).

Specimen Preparation

Transport 7 mL whole blood in the original collection tube. (Min: 0.5 mL)

Storage/Transport Temperature

Room temperature. Also acceptable: Refrigerated.

Unacceptable Conditions

Specimens collected in tubes other than Royal Blue (EDTA). Specimens transported in containers other than a Royal Blue (EDTA) tube or Trace Element-Free Transport Tube. Heparin anticoagulant. Clotted specimens.

Remarks
Stability

Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable

Reference Interval

Less than or equal to 2.0 µg/L

Interpretive Data

Elevated results may be due to skin or collection-related contamination, including the use of a noncertified metal-free collection/transport tube. If contamination concerns exist due to elevated levels of blood thallium, confirmation with a second specimen collected in a certified metal-free tube is recommended.

Blood thallium levels reflect recent exposure as thallium has a biological half-life of approximately 2 to 4 days. Blood levels greater than 100 µg/L are considered toxic and greater than 300 µg/L indicate severe ingestion. After severe thallium poisonings, reported symptoms have varying times of onset and include gastroenteritis, multi-organ failure and neurologic injury. Peripheral neuropathy and alopecia are well-documented effects of acute and chronic exposure. Human health effects from low-level thallium exposure are unknown.

Compliance Category

Laboratory Developed Test (LDT)

Note
Hotline History
N/A
CPT Codes

83018

Components
Component Test Code* Component Chart Name LOINC
0099610 Thallium, Blood 5743-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Tl
  • TLB
  • WB thallium
Thallium, Whole Blood