Ordering Recommendation

Serum nickel may be informative in the investigation of toxic exposure. Nickel, Urine (0025045) is the preferred test for the determination of exposure. Measurement of nickel is not recommended in asymptomatic individuals or individuals with a low likelihood of exposure.


Quantitative Inductively Coupled Plasma-Mass Spectrometry




1-3 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and non-essential over-the-counter medications (upon the advice of their physician).


Royal Blue (No Additive).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 2 mL serum within 2 hours of collection to an ARUP Trace Element-Free Transport Tube (ARUP supply #43116) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 0.5 mL)

Storage/Transport Temperature

Room temperature. Also acceptable: Refrigerated or frozen.

Unacceptable Conditions

Plasma. Specimens that are not separated from clot, within 2 hours. Separator tubes or Royal Blue (EDTA). Specimens transported in tubes other than specified. Hemolyzed specimens.


Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Indefinitely

Reference Interval

Less than or equal to 10.0 µg/L

Interpretive Data

Elevated results may be due to skin or collection-related contamination, including the use of a noncertified metal-free collection/transport tube. If contamination concerns exist due to elevated levels of serum nickel, confirmation with a second specimen collected in a certified metal-free tube is recommended.

Serum nickel testing is intended to detect potentially toxic exposure.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)


Hotline History


CPT Codes



Component Test Code* Component Chart Name LOINC
0099452 Nickel, Serum 5702-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Ni
  • Nickel serum level
  • NIS
Nickel, Serum