Urine is the preferred specimen for the determination of exposure. Measurement of nickel is not recommended in asymptomatic individuals or individuals with a low likelihood of exposure.
Quantitative Inductively Coupled Plasma-Mass Spectrometry
Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and non-essential over-the-counter medications (upon the advice of their physician). High concentrations of iodine may interfere with elemental testing. Abstinence from iodine-containing medications or contrast agents for at least 1 month prior to collecting specimens for elemental testing is recommended.
24-hour or random urine collection. Specimen must be collected in a plastic container. ARUP studies indicate that refrigeration of urine alone, during and after collection, preserves specimens adequately, if tested within 14 days of collection.
Transfer an 8 mL aliquot from a well-mixed collection to ARUP Trace Element-Free Transport Tubes (ARUP supply #43116). Available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 1 mL)
Refrigerated. Also acceptable: Room temperature or frozen.
Urine collected within 48 hours after administration of a gadolinium (Gd) containing contrast media (may occur with MRI studies). Acid preserved urine. Specimens contaminated with blood or fecal material. Specimens transported in non-trace element free transport tube (with the exception of the original device).
Record total volume and collection time interval on transport tube and on test request form.
Ambient: 1 week; Refrigerated: 2 weeks; Frozen: 1 year
|Nickel, Urine - per volume||0.0-10.4 µg/L|
|Nickel, Urine - per 24h||0.0-14.9 µg/d|
|Nickel, Urine - ratio to CRT||0.0-9.9 µg/g CRT|
|0020473||Creatinine, Urine - per 24h||
Measurement of nickel is not recommended in asymptomatic individuals or in individuals with a low likelihood of exposure. Elevations in nickel urine should be interpreted with caution in individuals with no exposure risks, and may indicate contamination of the specimen.
Laboratory Developed Test (LDT)
|Component Test Code*||Component Chart Name||LOINC|
|0020207||Creatinine, Urine - per volume||2161-8|
|0020208||Creatinine, Urine - per 24h||2162-6|
|0025044||Nickel, Urine - ratio to CRT||29936-2|
|0025046||Nickel, Urine - per volume||14099-6|
|0025047||Nickel, Urine - per 24h||5705-9|
- Ni Urine
- Nickel/Creatinine Ratio, Random, Urine
- Normalized Urine Nickel
- Urine nickel concentration