Use to evaluate vitamin B12 deficiency in individuals with macrocytic or unexplained anemia, or unexplained neurologic disease. Preferred test is Vitamin B12 with Reflex to Methylmalonic Acid, Serum (Vitamin B12 Status) (0055662).
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Plain red or serum separator tube. Also acceptable: Green (sodium heparin), green (lithium heparin), lavender (EDTA), or pink (K2EDTA).
Centrifuge and remove serum or plasma from cells within 2 hours of collection. Transfer 1.2 mL serum or plasma to an ARUP Standard Transport Tube and refrigerate or freeze immediately. (Min: 0.6 mL)
Room temperature specimens. Grossly hemolyzed or lipemic specimens.
After separation from cells: Ambient: Unacceptable; Refrigerated: 1 week; Frozen: 1 month
Compliance Statement B: For laboratory developed tests not using a RUO kit, and for FDA approved, cleared or 510(k) exempt assays with alterations. This test was developed and its performance characteristics determined by ARUP Laboratories. The U. S. Food and Drug Administration has not approved or cleared this test; however, FDA clearance or approval is not currently required for clinical use. The results are not intended to be used as the sole means for clinical diagnosis or patient management decisions.
|Component Test Code*||Component Chart Name||LOINC|
|0099431||MMA Serum/Plasma, Vitamin B12 Status||13964-2|
- Cobalamin Deficiency (Methylmalonic Acid, Serum or Plasma (Vitamin B12 Deficiency))
- Methylmalonate (Methylmalonic Acid, Serum or Plasma (Vitamin B12 Deficiency))
- MMA (Methylmalonic Acid, Serum or Plasma (Vitamin B12 Deficiency))
- Vitamin B12 Deficiency (Methylmalonic Acid, Serum or Plasma (Vitamin B12 Deficiency))