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Vitamin B12 with Reflex to Methylmalonic Acid, Serum (Vitamin B12 Status)
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Ordering Recommendation
Preferred reflex test for the evaluation of vitamin B12 deficiency in individuals with macrocytic or unexplained anemia, or unexplained neurologic disease.
Mnemonic
Methodology
Quantitative Chemiluminescent Immunoassay/Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry
Performed
Sun-Sat
Reported
1-3 days
New York DOH Approval Status
Specimen Required
Plain red or serum separator tube. Also acceptable: Green (sodium or lithium heparin).
Protect from light during collection, storage and shipment. Centrifuge and remove serum from cells within 2 hours of collection. Transfer 2 mL serum or plasma to an ARUP Standard Transport Tube and refrigerate or freeze immediately. (Min: 1.5 mL)
Frozen.
EDTA plasma. Room temperature specimens. Grossly hemolyzed or lipemic specimens.
After separation from cells: Ambient: Unacceptable; Refrigerated: 48 hours; Frozen: 1 month
Reference Interval
| Available Separately |
Components |
Reference Interval |
|---|---|---|
| Yes (0070150) | Vitamin B12 | Effective December 2, 2013 180-914 pg/mL |
| No | Methylmalonic Acid, Serum (Vitamin B12 Deficiency) | 0.00-0.40 µmol/L |
Interpretive Data
FDA
Note
If Vitamin B12 is less than 300 pg/mL, then Methylmalonic Acid, Serum (Vitamin B12 Status) will be added. Additional charges apply.
Hotline History
CPT Codes
82607; if reflexed, add 83921
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0055663 | Vitamin B12 Status | 2132-9 |
| 0055664 | Methylmalonic Acid, Serum | 13964-2 |
Aliases
- B12 (Cobalamin)
- B12 and MMA reflex
- B12 Assay
- B12 MMA
- B12, Serum
- CblC
- Cobalamin
- Methylcobalamin
- Vit B12 and MMA
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