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Vitamin B12 with Reflex to Methylmalonic Acid, Serum (Vitamin B12 Status)
Ordering Recommendation
Preferred reflex test for the evaluation of vitamin B12 deficiency in individuals with macrocytic or unexplained anemia, or unexplained neurologic disease.
Methodology
Quantitative Chemiluminescent Immunoassay (CLIA)/Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Performed
Sun-Sat
Reported
1-3 days
New York DOH Approval Status
Specimen Required
Plain red or serum separator tube. Also acceptable: Green (sodium or lithium heparin).
Protect from light during collection, storage and shipment. Centrifuge and remove serum from cells within 2 hours of collection. Transfer 2 mL serum or plasma to an ARUP Standard Transport Tube and refrigerate or freeze immediately. (Min: 1.5 mL)
Frozen.
EDTA plasma. Room temperature specimens. Grossly hemolyzed or lipemic specimens.
After separation from cells: Ambient: Unacceptable; Refrigerated: 48 hours; Frozen: 1 month
Reference Interval
| Available Separately |
Components |
Reference Interval |
|---|---|---|
| Yes (0070150) | Vitamin B12 | Effective December 2, 2013 180-914 pg/mL |
| No | Methylmalonic Acid, Serum (Vitamin B12 Deficiency) | 0.00-0.40 µmol/L |
Interpretive Data
FDA
Note
If Vitamin B12 is less than 300 pg/mL, then Methylmalonic Acid, Serum (Vitamin B12 Status) will be added. Additional charges apply.
Hotline History
CPT Codes
82607; if reflexed, add 83921
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0055663 | Vitamin B12 Status | 2132-9 |
| 0055664 | Methylmalonic Acid, Serum | 13964-2 |
Aliases
- B12 (Cobalamin)
- B12 and MMA reflex
- B12 Assay
- B12 MMA
- B12, Serum
- CblC
- Cobalamin
- Methylcobalamin
- Vit B12 and MMA
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