Vitamin B12 with Reflex to Methylmalonic Acid, Serum (Vitamin B12 Status)

0055662
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Example Reports
High
Normal

Ordering Recommendation

Preferred reflex test for the evaluation of vitamin B12 deficiency in individuals with macrocytic or unexplained anemia, or unexplained neurologic disease.

Mnemonic

B12 MMA

Methodology

Quantitative Chemiluminescent Immunoassay/Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry

Performed

Sun-Sat

Reported

1-3 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Plain red or serum separator tube. Also acceptable: Green (sodium or lithium heparin).

Specimen Preparation

Protect from light during collection, storage and shipment. Centrifuge and remove serum from cells within 2 hours of collection. Transfer 2 mL serum or plasma to an ARUP Standard Transport Tube and refrigerate or freeze immediately. (Min: 1.5 mL)

Storage/Transport Temperature

Frozen.

Unacceptable Conditions

EDTA plasma. Room temperature specimens. Grossly hemolyzed or lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: Unacceptable; Refrigerated: 48 hours; Frozen: 1 month

Reference Interval

Available Separately
 Components
 Reference Interval
Yes (0070150) Vitamin B12 Effective December 2, 2013
180-914 pg/mL
No Methylmalonic Acid, Serum (Vitamin B12 Deficiency) 0.00-0.40 µmol/L

Interpretive Data



Compliance Category

FDA

Note

If Vitamin B12 is less than 300 pg/mL, then Methylmalonic Acid, Serum (Vitamin B12 Status) will be added. Additional charges apply.

Hotline History

N/A

CPT Codes

82607; if reflexed, add 83921

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Components

Component Test Code* Component Chart Name LOINC
0055663 Vitamin B12 Status 2132-9
0055664 Methylmalonic Acid, Serum 13964-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • B12 (Cobalamin)
  • B12 and MMA reflex
  • B12 Assay
  • B12 MMA
  • B12, Serum
  • CblC
  • Cobalamin
  • Methylcobalamin
  • Vit B12 and MMA
Vitamin B12 with Reflex to Methylmalonic Acid, Serum (Vitamin B12 Status)