Ordering Recommendation

May be useful as a reasonable indicator of recent, active exposure and provides a modest indicator for distinguishing exposed from nonexposed individuals. Not recommended for the assessment of manganese body stores. Manganese, Whole Blood (0099272) is recommended for monitoring potential accumulation with TPN.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, and non-essential over-the-counter medications (upon the advice of their physician).


Royal Blue (No Additive).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 2 mL serum to an ARUP Trace Element-Free Transport Tube (ARUP supply #43116) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787. (Min: 0.5 mL)

Storage/Transport Temperature

Room temperature.

Unacceptable Conditions

Plasma. Specimens that are not separated from clot, within 2 hours. Separator tubes or Royal Blue (EDTA). Specimens transported in tubes other than specified. Hemolyzed specimens.


Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Indefinitely


Quantitative Inductively Coupled Plasma-Mass Spectrometry




1-5 days

Reference Interval

0.0-2.0 µg/L

Interpretive Data

Elevated results may be due to skin or collection-related contamination, including the use of a noncertified metal-free collection/transport tube. If contamination concerns exist due to elevated levels of serum manganese, confirmation with a second specimen collected in a certified metal-free tube is recommended.

Less than 5 percent of manganese present in circulation resides in the serum.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)


Hotline History


CPT Codes



Component Test Code* Component Chart Name LOINC
0099265 Manganese, Serum 5683-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Mn
  • Mn blood level
  • MNS
  • Serum manganese concentration
Manganese, Serum