Optimize drug therapy and monitor patient adherence.
Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.
Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA).
Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).
After separation from cells: Ambient: 5 days; Refrigerated: 2 weeks; Frozen: 6 months
Effective November 18, 2013
|Therapeutic Range:||Not well established.|
|Toxic:||Greater than 300 ng/mL|
Sertraline doses ranging from 50-200 mg/d produce serum concentration ranging from 30-200 ng/mL. Dosing above 200 mg/d is associated with increased adverse effects and decreased efficacy. Adverse effects may include dry mouth, headache, dizziness, somnolence, nausea and diarrhea.
Laboratory Developed Test (LDT)
80332 (Alt code: G0480)
|Component Test Code*||Component Chart Name||LOINC|
- sertraline blood level
- zoloft blood level