Use to optimize drug therapy and monitor patient adherence.
Liquid Chromatography-Tandem Mass Spectrometry
New York DOH Approval Status
Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.
Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA).
Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).
After separation from cells: Ambient: 24 hours; Refrigerated: 2 weeks; Frozen: 4 months
|Sertraline_Serum or Plasma||
Sertraline is a selective serotonin reuptake inhibitor antidepressant drug indicated for the treatment of major depressive disorder, obsessive-compulsive disorder, posttraumatic stress disorder, social anxiety disorder, and premenstrual dysphoric disorder. Sertraline doses range from 50-200 mg/day to produce serum concentration that range from 30-200 ng/mL. Dosing above 200 mg/day may increase the risk of adverse effects. Adverse effects may include dry mouth, headache, dizziness, fatigue, somnolence, tremor, nausea, and diarrhea. The risk of serotonin syndrome is increased with concomitant use of other serotonergic drugs. Concomitant use of sertraline with anticoagulants and nonsteroidal anti-inflammatory drugs may increase the risk of bleeding.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the U.S. Food and Drug Administration. This test was performed in a CLIA-certified laboratory and is intended for clinical purposes.
Laboratory Developed Test (LDT)
80332 (Alt code: G0480)
|Component Test Code*||Component Chart Name||LOINC|
|3005861||Sertraline_Serum or Plasma|