Ordering Recommendation

Rarely indicated in clinical practice. The preferred test for the measurement of estrone is Estrogens, Fractionated, by Mass Spectrometry (0093248).

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Serum separator tube, lavender (EDTA), pink (K2EDTA), or green (sodium or lithium heparin).

Specimen Preparation

Separate serum or plasma from cells within 2 hours of collection. Transfer 0.5 mL serum or plasma to an ARUP Standard Transport Tube. (Min 0.3 mL)

Storage/Transport Temperature


Unacceptable Conditions

After separation from cells: Ambient: 48 hours; Refrigerated: 1 week; Frozen: 1 month


Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry




1-5 days

Reference Interval

Test Number
Reference Interval
  Estrone by Mass Spec
Age Male (pg/mL) Female (pg/mL)
7-9 years Less than 7.0 Less than 20.0
10-12 years Less than 11.0 1.0-40.0
13-15 years 1.0-30.0 8.0-105.0
16-17 years 1.0-32.0 4.0-133.0
18 years and older 9.0-36.0 Premenopausal
Early Follicular: Less than 150.0
Late Follicular: 100.0-250.0.
Luteal: Less than 200.0

Postmenopausal: 3.0-32.0
Tanner Stage I Less than 7.0 Less than 27.0
Tanner Stage II Less than 11.0 1.0-39.0
Tanner Stage III 1.0-31.0 8.0-117.0
Tanner Stage IV-V 2.0-30.0 4.0-109.0

Interpretive Data

For a complete set of all established reference intervals, refer to ltd.aruplab.com/Tests/Pub/0093249.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)


Hotline History


CPT Codes



Component Test Code* Component Chart Name LOINC
0093249 Estrone by Mass Spec 2258-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Estrone (E1)
Estrone, by Mass Spectrometry