Recommendations when to order or not order the test. May include related or preferred tests.
Use to evaluate estrogen status in children, cisgender males, and postmenopausal cisgender females. Most useful when low estrogen concentrations are expected, regardless of the patient’s sex assigned at birth.
Mnemonic
Unique test identifier.
EST FR TMS
Methodology
Process(es) used to perform the test.
Quantitative High Performance Liquid Chromatography-Tandem Mass Spectrometry
Performed
Days of the week the test is performed.
Sun-Sat
Reported
Expected turnaround time for a result, beginning when ARUP has received the specimen.
1-4 days
New York DOH Approval Status
Indicates test has been approved by the New York State Department of Health.
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect
Serum separator tube, lavender (EDTA), pink (K2EDTA), or green (sodium or lithium heparin).
Specimen Preparation
Separate serum or plasma from cells within 2 hours of collection. Transfer 0.5 mL serum or plasma to an ARUP Standard Transport Tube. (Min 0.3 mL)
Storage/Transport Temperature
Refrigerated.
Unacceptable Conditions
Remarks
Stability
After separation from cells: Ambient: 48 hours; Refrigerated: 1 week; Frozen: 1 month
Reference Interval
Normal range/expected value(s) for a specific disease state. May also include abnormal ranges.
Test Number
Components
Reference Interval
Estradiol by Mass Spec
Age
Male (pg/mL)
Female (pg/mL)
7-9 years
Less than 7.0
Less than 36.0
10-12 years
Less than 11.0
1.0-87.0
13-15 years
1.0-36.0
9.0-249.0
16-17 years
3.0-34.0
2.0-266.0
18 years and older
10.0-42.0
Premenopausal Early Follicular: 30.0-100.0 Late Follicular: 100.0-400.0 Luteal: 50.0-150.0
Postmenopausal: 2.0-21.0
Tanner Stage I
Less than 8.0
Less than 56.0
Tanner Stage II
Less than 10.0
2.0-133.0
Tanner Stage III
1.0-35.0
12.0-277.0
Tanner Stage IV-V
3.0-35.0
2.0-259.0
Estrone by Mass Spec
Age
Male (pg/mL)
Female (pg/mL)
7-9 years
Less than 7.0
Less than 20.0
10-12 years
Less than 11.0
1.0-40.0
13-15 years
1.0-30.0
8.0-105.0
16-17 years
1.0-32.0
4.0-133.0
18 years and older
9.0-36.0
Premenopausal Early Follicular: Less than 150.0 Late Follicular: 100.0-250.0. Luteal: Less than 200.0
Postmenopausal: 3.0-32.0
Tanner Stage I
Less than 7.0
Less than 27.0
Tanner Stage II
Less than 11.0
1.0-39.0
Tanner Stage III
1.0-31.0
8.0-117.0
Tanner Stage IV-V
2.0-30.0
4.0-109.0
Estrogens Total Calculation
Age
Male (pg/mL)
Female (pg/mL)
7-9 years
Less than 10.0
1.0-48.0
10-12 years
1.0-19.0
2.0-116.0
13-15 years
3.0-62.0
15.0-333.0
16-17 years
4.0-64.0
6.0-354.0
18 years or older
19.0-69.0
Premenopausal Early Follicular: 30.0-250.0 Late Follicular: 200.0-650.0 Luteal: 50.0-350.0
Postmenopausal: 5.0-52.0
Tanner Stage I
1.0-11.0
1.0-86.0
Tanner Stage II
1.0-19.0
3.0-169.0
Tanner Stage III
3.0-61.0
23.0-351.0
Tanner Stage IV-V
4.0-62.0
8.0-341.0
Interpretive Data
Background information for test. May include disease information, patient result explanation, recommendations, details of testing, associated diseases, explanation of possible patient results.
For a complete set of all established reference intervals, refer to ltd.aruplab.com/Tests/Pub/0093248.
This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.
Compliance Category
Laboratory Developed Test (LDT)
Note
Additional information related to the test.
Hotline History
N/A
CPT Codes
The American Medical Association Current Procedural Terminology (CPT) codes published in ARUP's Laboratory Test Directory are provided for informational purposes only. The codes reflect our interpretation of CPT coding requirements based upon AMA guidelines published annually. CPT codes are provided only as guidance to assist clients with billing. ARUP strongly recommends that clients confirm CPT codes with their Medicare administrative contractor, as requirements may differ. CPT coding is the sole responsibility of the billing party. ARUP Laboratories assumes no responsibility for billing errors due to reliance on the CPT codes published.
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
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