Ordering Recommendation

Use to obtain quantitative results or to follow up a presumptive result. For general screening, the preferred test is Fentanyl, Urine Screen with Reflex to Quantitation (2012284).

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Random urine.

Specimen Preparation

Transfer 4 mL urine with no additives or preservatives to an ARUP standard transport tube. (Min: 0.5 mL)

Storage/Transport Temperature

Room temperature.

Unacceptable Conditions

Specimens exposed to repeated freeze/thaw cycles.


Ambient: 1 month; Refrigerated: 1 month; Frozen: 9 months


Quantitative Liquid Chromatography-Tandem Mass Spectrometry




1-5 days

Reference Interval

Drugs Covered Cutoff Concentrations
Fentanyl 1.0 ng/mL
Norfentanyl 1.0 ng/mL

Interpretive Data

Methodology: Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Positive cutoff: 1.0 ng/mL

For medical purposes only; not valid for forensic use.

The absence of expected drug(s) and/or drug metabolite(s) may indicate noncompliance, inappropriate timing of specimen collection relative to drug administration, poor drug absorption, diluted/adulterated urine, or limitations of testing. The concentration value must be greater than or equal to the cutoff to be reported as positive. Interpretive questions should be directed to the laboratory.

Compliance Category

Laboratory Developed Test (LDT)


Compare to Fentanyl, Quantitative, with medMATCH, Urine.

Hotline History


CPT Codes

80354 (Alt code: G0480)


Component Test Code* Component Chart Name LOINC
2005886 Fentanyl, Urn, Quant 3637-6
2005887 Norfentanyl, Urn, Quant 11075-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Actiq
  • Duragesic
  • Durogesic
  • fentanyl and norfentanyl urine concentrations
  • Fentora
  • Innovar
  • Instanyl
  • Ionsys
  • Onsolis
  • Sublimaze
Fentanyl and Metabolite, Urine, Quantitative