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Time Sensitive

Ordering Recommendation

• Use for infant drug testing when only methadone exposure is of clinical interest or when quantity of meconium available for testing is very small (eg, <1 g).
• Preferred test is Drugs of Abuse Panel, Meconium - Screen with Reflex to Confirmation/Quantitation (0092516).

Mnemonic

CONFMTD M

Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry

Performed

Sun-Sat

Reported

1-4 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

All meconium (blackish material) excreted until milk/formula based stool (yellow-green) appears.

Specimen Preparation

Transport 0.5 g (equivalent to 1/2 inch cube) for each separate confirmation required. (Min: 0.13 g or 1/4 inch cube)

Storage/Transport Temperature

Room temperature.

Unacceptable Conditions
Remarks
Stability

Ambient: 1 week; Refrigerated: 3 months; Frozen: 1 year

Reference Interval

Interpretive Data

Drugs Covered: methadone and metabolite (EDDP).
Positive cutoff:
10 ng/g

Meconium begins to form between the 12th and 16th week of gestation. Meconium drug testing can detect maternal drug use during the last 4 to 5 months of pregnancy. A negative result does not exclude the possibility that a mother used drugs during pregnancy. Detection of drug use depends on the quantity and quality of the specimen tested as well as the pattern and frequency of drug(s) used by mother. The concentration value must be greater than or equal to the cutoff to be reported as positive. Interpretive questions should be directed to the laboratory.

For medical purposes only; not valid for forensic use.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)

Note

Hotline History

N/A

CPT Codes

80358 (Alt code: G0480)

Components

Component Test Code* Component Chart Name LOINC
0092313 Drug Confirmation, Methadone/Metab, Mec 29159-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Amidone
  • Dolophine
  • EDDP
  • Heptadon
  • Methadone
  • Methadose
  • Physeptone
  • Symoron
Drugs of Abuse Confirmation/Quantitation - Methadone and Metabolite - Meconium