Ordering Recommendation

Use to detect and document fetal drug exposure during approximately the last trimester of a full-term pregnancy. For panel testing that includes THC metabolite, refer to Drug Detection Panel and THC Metabolite, Meconium, Qualitative (3006373).

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

All meconium (blackish material) excreted until milk/formula-based stool (yellow-green) appears.

Specimen Preparation

Transport all available meconium (4 g is preferred) to routine urine collection cup or Security Kit for Meconium/Umbilical Drug Detection (ARUP supply #51548) available online through eSupply using ARUP Connect™ or by contacting ARUP Client Services at  800-522-2787.

Storage/Transport Temperature

Refrigerated temperature.

Unacceptable Conditions

Unknown fluids, pharmaceutical preparation, and breast milk. Diapers, cotton swabs, baby wipes, tongue depressors, bottles.


Ambient: 1 week; Refrigerated: 3 weeks; Frozen: 1 year


Qualitative Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)




1-3 days

Reference Interval

Drugs covered and range of cutoff concentrations.
Drugs/Drug Classes
Cutoff Concentrations (ng/g)
Drugs/Drug Classes
Cutoff Concentrations (ng/g)
Buprenorphine 20 Amphetamine 20
Norbuprenorphine 20 Benzoylecgonine 20
Naloxone 20 m-OH-Benzoylecgonine 20
Codeine 20 Cocaethylene 20
Dihydrocodeine 20 Cocaine 20
Fentanyl 10 MDMA (Ecstasy) 20
Hydrocodone 20 Methamphetamine 20
Norhydrocodone 20 Phentermine 20
Hydromorphone 20 Alprazolam 5
Meperidine 20 Alpha-OH-Alprazolam 5
Methadone 10 Butalbital 50
Methadone metabolite 10 Clonazepam 5
6-Acetylmorphine 20 7-Aminoclonazepam 5
Morphine 20 Diazepam 5
Methylphenidate 20 Lorazepam 20
Oxycodone 20 Midazolam 20
Noroxycodone 20 Alpha-OH-Midazolam 20
Oxymorphone 20 Nordiazepam 20
Tapentadol 20 Oxazepam 20
Tramadol 20 Phenobarbital 200
N-desmethyltramadol 20 Temazepam 20
O-desmethyltramadol 20 Zolpidem 10
Gabapentin 20 Phencyclidine (PCP) 10
Mitragynine (Kratom) 25

Interpretive Data

Methodology: Qualitative Liquid Chromatography/Tandem Mass Spectrometry

Detection of drugs in meconium is intended to reflect maternal drug use during approximately the last trimester of a full-term pregnancy. The pattern and frequency of drug(s) used by the mother cannot be determined by this test. A negative result does not exclude the possibility that a mother used drugs during pregnancy. Detection of drugs in meconium depends on the extent of maternal drug use, as well as drug stability, unique characteristics of drug deposition in meconium, and the performance of the analytical method. Drugs administered during labor and delivery may be detected. Detection of drugs in meconium does not insinuate impairment and may not affect outcomes for the infant. Interpretive questions should be directed to the laboratory.

For medical purposes only; not valid for forensic use.

Compliance Category

Laboratory Developed Test (LDT)


When ordering both meconium tests, unless ARUP is otherwise notified, testing will be performed in the following order of priority:

Drug Detection Panel (0.125g)
Marijuana (0.125g)

Hotline History


CPT Codes

80326; 80347; 80364; 80355; 80323 (Alt code: G0481)


Component Test Code* Component Chart Name LOINC
3004673 6-Acetylmorphine, MEC, Qual 32099-4
3004674 7-Aminoclonazepam, MEC, Qual 61031-1
3004675 Alpha-OH-Alprazolam, MEC, Qual 61037-8
3004676 Alpha-OH-Midazolam, MEC, Qual
3004677 Alprazolam, MEC, Qual 61038-6
3004678 Amphetamine, MEC, Qual 8144-8
3004679 Benzoylecgonine, MEC, Qual 8187-7
3004680 Buprenorphine, MEC, Qual
3004681 Butalbital, MEC, Qual 32057-2
3004682 Clonazepam, MEC, Qual 61039-4
3004683 Cocaethylene, MEC, Qual 57945-8
3004684 Cocaine, MEC, Qual 40527-4
3004685 Codeine, MEC, Qual 29278-9
3004686 Diazepam, MEC, Qual 61074-1
3004687 Dihydrocodeine, MEC, Qual
3004688 Methadone Metabolite, MEC, Qual 91030-7
3004689 Fentanyl, MEC, Qual 61042-8
3004690 Gabapentin, MEC, Qual
3004691 Hydrocodone, MEC, Qual 57981-3
3004692 Hydromorphone, MEC, Qual 57982-1
3004693 Lorazepam, MEC, Qual 61044-4
3004694 MDMA- Ecstasy, MEC, Qual 40481-4
3004695 Meperidine, MEC, Qual 75647-8
3004696 Methadone, MEC, Qual 43595-8
3004697 Methamphetamine, MEC, Qual 29286-2
3004698 Methylphenidate, MEC, Qual 61050-1
3004699 Midazolam, MEC, Qual
3004700 m-OH-Benzoylecgonine, MEC, Qual 91029-9
3004701 Morphine, MEC, Qual 29287-0
3004702 Naloxone, MEC, Qual
3004703 N-desmethyltramadol, MEC, Qual
3004704 Norbuprenorphine, MEC, Qual 82375-7
3004705 Nordiazepam, MEC, Qual 61051-9
3004706 Norhydrocodone, MEC, Qual
3004707 Noroxycodone, MEC, Qual
3004708 O-desmethyltramadol, MEC, Qual
3004709 Oxazepam, MEC, Qual 61055-0
3004710 Oxycodone, MEC, Qual 32101-8
3004711 Oxymorphone, MEC, Qual
3004712 Phencyclidine- PCP, MEC, Qual 8232-1
3004713 Phenobarbital, MEC, Qual 32108-3
3004714 Phentermine, MEC, Qual
3004715 Tapentadol, MEC, Qual
3004724 Temazepam, MEC, Qual 61061-8
3004725 Tramadol, MEC, Qual 93719-3
3004726 Zolpidem, MEC, Qual
3004739 EER Drug Detection Pan, MEC 11502-2
3004740 Drug Detection Panel, MEC 58738-6
3016645 Mitragynine, MEC, Qual
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


Drug Detection Panel, Meconium, Qualitative