Oligoclonal Bands in CSF and Serum
May be used in the assessment of multiple sclerosis to detect unique IgG oligoclonal bands in cerebrospinal fluid (CSF) in conjunction with a matched serum specimen. The preferred test to assess for multiple sclerosis is Oligoclonal Band Profile (0080440).
Qualitative Isoelectric Focusing/Electrophoresis
New York DOH Approval Status
CSF AND serum separator tube or plain red. Serum specimen should be drawn within 48 hours of CSF collection.
Allow serum to clot completely at room temperature. Separate serum from cells ASAP or within 2 hours of collection. Transport 1.5 mL CSF (Min: 0.7 mL) AND transfer 1 mL serum to an ARUP Standard Transport Tube (Min: 0.6 mL).
Grossly bloody or hemolyzed specimens or severe lipemia
Ambient: Unacceptable; Refrigerated: 14 days; Frozen: 6 months
Effective August 6, 2012
|0081139||Oligoclonal Bands, CSF||Negative|
|2005461||Oligoclonal Bands Number, CSF||0 - 1 Bands|
Specimens must be assayed together for interpretation.
This test reports only the number of oligoclonal bands. A patient is considered positive for CSF oligoclonal bands if there are two or more bands in the CSF immunoglobulin region that are not present in the serum. In order to confirm local production of oligoclonal IgG in CSF, a matched serum sample is required. Oligoclonal bands present in CSF, but not in serum, indicate central nervous system production. Oligoclonal bands are performed using isoelectric focusing and immunofixation.
|Component Test Code*||Component Chart Name||LOINC|
|0081139||Oligoclonal Bands, CSF||48668-8|
|2005461||Oligoclonal Bands Number, CSF||49852-7|
|2005464||Oligoclonal Bands Interpretation||49293-4|
- CSF oligoclonal bands
- Oligoclonal Bands Only
- Oligoclonal IgG, CSF
- Oliogoclonal bands, CSF