Oligoclonal Bands in CSF and Serum

0081135
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Example Reports
Abnormal
Normal
Ordering Recommendation

Use for assessment of multiple sclerosis. Detect unique IgG oligoclonal bands in cerebrospinal fluid (CSF) in conjunction with a matched serum specimen. Preferred test is Oligoclonal Band Profile (0080440).

Mnemonic
OLIGOB
Methodology

Qualitative Isoelectric Focusing/Electrophoresis

Performed

Sun-Sat

Reported

1-3 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

CSF AND serum separator tube or plain red. Serum specimen should be drawn within 48 hours of CSF collection.

Specimen Preparation

Allow serum to clot completely at room temperature. Separate serum from cells ASAP or within 2 hours of collection. Transport 1.5 mL CSF (Min: 0.7 mL) AND transfer 1 mL serum to an ARUP Standard Transport Tube (Min: 0.6  mL).

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Grossly bloody or hemolyzed specimens or severe lipemia

Remarks
Stability

Ambient: Unacceptable; Refrigerated: 14 days; Frozen: 6 months

Reference Interval

Effective August 6, 2012

Test Number
 Components
 Reference Interval
0081139 Oligoclonal Bands, CSF Negative
2005461 Oligoclonal Bands Number, CSF 0 - 1 Bands
Interpretation By report

Interpretive Data



Compliance Category

FDA

Note

Specimens must be assayed together for interpretation.
This test reports only the number of oligoclonal bands.  A patient is considered positive for CSF oligoclonal bands if there are two or more bands in the CSF immunoglobulin region that are not present in the serum. In order to confirm local production of oligoclonal IgG in CSF, a matched serum sample is required. Oligoclonal bands present in CSF, but not in serum, indicate central nervous system production. Oligoclonal bands are performed using isoelectric focusing and immunofixation.

Hotline History

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Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
02/15/2021
X
N/A
CPT Codes

83916

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Components
Component Test Code* Component Chart Name LOINC
0081139 Oligoclonal Bands, CSF 48668-8
2005461 Oligoclonal Bands Number, CSF 49852-7
2005464 Oligoclonal Bands Interpretation 49293-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • CSF oligoclonal bands
  • Oligoclonal Bands Only
  • Oligoclonal IgG, CSF
  • Oliogoclonal bands, CSF
Oligoclonal Bands in CSF and Serum