Ordering Recommendation

Preferred test in the workup of multiple sclerosis. Detect unique IgG oligoclonal bands in cerebrospinal fluid (CSF) in conjunction with a matched serum specimen. Calculate CSF IgG index.

Mnemonic
OLIGO
Methodology

Qualitative Isoelectric Focusing/Electrophoresis/Nephelometry

Performed

Sun-Sat

Reported

1-3 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

CSF AND serum separator tube or plain red. Serum specimen should be drawn within 48 hours of CSF collection.

Specimen Preparation

Allow serum to clot completely at room temperature. Separate serum from cells ASAP or within 2 hours of collection. Transport 1.5 mL CSF. (Min: 0.7 mL) AND transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions
Remarks
Stability

Ambient: 8 hours; Refrigerated: 1 week; Frozen: 1 year

Reference Interval
Test Number
Components
Reference Interval
0050350 Immunoglobulin G
0- 30 days: 611-1542 mg/dL              
1 month: 241-870 mg/dL                          
2 months: 198-577 mg/dL            
3 months: 169-558 mg/dL                    
4 months: 188-536 mg/dL                          
5 months: 165-781 mg/dL                          
6 months: 206-676 mg/dL                           
7-8 months: 208-868 mg/dL                        
9-11 months: 282-1026 mg/dL
1 year: 331-1164 mg/dL
2 years: 407-1009 mg/dL
3 years: 423-1090 mg/dL
4 years: 444-1187 mg/dL
5-7 years: 608-1229 mg/dL
8-9 years: 584-1509 mg/dL
10 years and older: 768-1632 mg/dL

0050670 Immunoglobulin G, CSF 0-6.0 mg/dL
0050200 Albumin, CSF 0-35 mg/dL
  Albumin Index 0.0-9.0
  CSF IgG/Albumin Ratio 0.09-0.25
  IgG Index 0.28-0.66
  CSF Oligoclonal Bands Negative
  Interpretation By report
  CSF IgG Synthesis Rate Less than or equal to 8.0 mg/d
0050671 Albumin by Nephelometry 3500-5200 mg/dL
  Oligoclonal Bands Number, CSF 0 - 1 Bands

Interpretive Data



Compliance Category

FDA

Note

Specimens must be assayed together for interpretation.
A patient is considered positive for CSF oligoclonal bands if there are two or more bands in the CSF immunoglobulin region that are not present in the serum. In order to confirm local production of oligoclonal IgG in CSF, a matched serum sample is required. Oligoclonal bands present in CSF, but not in serum, indicate central nervous system production. Oligoclonal bands are performed using isoelectric focusing and immunofixation.

Hotline History
N/A
CPT Codes

83916; 82784 x2; 82040; 82042

Components
Component Test Code* Component Chart Name LOINC
0050200 Albumin, CSF 1746-7
0050350 Immunoglobulin G 2465-3
0050670 Immunoglobulin G CSF 2464-6
0050671 Albumin by Nephelometry 1751-7
0050672 Albumin Index 1756-6
0050675 CSF IgG Synthesis Rate 14116-8
0080095 CSF Oligoclonal Bands 12782-9
0080099 Interpretation 49293-4
0080175 CSF IgG/Albumin Ratio 2470-3
0080180 IgG Index 14117-6
2005461 Oligoclonal Bands Number, CSF 49852-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • CSF Oligoclonal Bands
  • MS Panel
  • MS Profile
  • Multiple Sclerosis Panel
  • Multiple Sclerosis Panel without Myelin Basic Protein
  • Multiple Sclerosis Profile
  • Oligoclonal Banding
Oligoclonal Band Profile