Preferred test in the workup of multiple sclerosis. Detect unique IgG oligoclonal bands in cerebrospinal fluid (CSF) in conjunction with a matched serum specimen. Calculate CSF IgG index.
Qualitative Isoelectric Focusing/Electrophoresis/Quantitative Immunoturbidimetry
Sun-Sat
1-3 days
CSF AND serum separator tube or plain red. Serum specimen should be drawn within 48 hours of CSF collection.
Allow serum to clot completely at room temperature. Separate serum from cells ASAP or within 2 hours of collection. Transport 1.5 mL CSF. (Min: 1.0 mL) AND transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.6 mL)
Refrigerated.
Grossly bloody or hemolyzed specimens or severe lipemia.
Ambient: Unacceptable; Refrigerated: 2 week; Frozen: 6 months
Test Number |
Components |
Reference Interval |
||
---|---|---|---|---|
0050350 | Immunoglobulin G | Effective February 16, 2021
|
||
3003485 | Immunoglobulin G, CSF | 0.0-6.0 mg/dL | ||
0050200 | Albumin, CSF | 0-35 mg/dL | ||
Albumin Index | 0.0-9.0 | |||
CSF IgG/Albumin Ratio | 0.09-0.25 | |||
IgG Index | 0.28-0.66 | |||
CSF Oligoclonal Bands | Negative | |||
Interpretation | By report | |||
CSF IgG Synthesis Rate | Less than or equal to 8.0 mg/d | |||
Albumin, Serum | 3500-5200 mg/dL | |||
Oligoclonal Bands Number, CSF | 0 - 1 Bands | |||
FDA
Specimens must be assayed together for interpretation.
A patient is considered positive for CSF oligoclonal bands if there are two or more bands in the CSF immunoglobulin region that are not present in the serum. In order to confirm local production of oligoclonal IgG in CSF, a matched serum sample is required. Oligoclonal bands present in CSF, but not in serum, indicate central nervous system production. Oligoclonal bands are performed using isoelectric focusing and immunofixation.
Hotline History
83916; 82784 x2; 82040; 82042
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0050200 | Albumin, CSF | 1746-7 |
0050350 | Immunoglobulin G | 2465-3 |
0050670 | Immunoglobulin G CSF | 2464-6 |
0050671 | Albumin, Serum | 1751-7 |
0050672 | Albumin Index | 1756-6 |
0050675 | CSF IgG Synthesis Rate | 14116-8 |
0080095 | CSF Oligoclonal Bands | 12782-9 |
0080099 | Interpretation | 49293-4 |
0080175 | CSF IgG/Albumin Ratio | 2470-3 |
0080180 | IgG Index | 14117-6 |
2005461 | Oligoclonal Bands Number, CSF | 49852-7 |
- CSF Oligoclonal Bands
- MS Panel
- MS Profile
- Multiple Sclerosis Panel
- Multiple Sclerosis Panel without Myelin Basic Protein
- Multiple Sclerosis Profile
- Oligoclonal Banding