Ordering Recommendation

Preferred test in the assessment of multiple sclerosis to detect unique IgG oligoclonal bands in cerebrospinal fluid (CSF) in conjunction with a matched serum specimen. Test calculates CSF IgG index.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

CSF AND serum separator tube or plain red.

Specimen Preparation

Allow serum to clot completely at room temperature. Separate serum from cells ASAP or within 2 hours of collection. Transport 1.5 mL CSF. (Min: 1.0 mL) AND transfer 1 mL serum to an ARUP standard transport tube. (Min: 0.6 mL)

Storage/Transport Temperature


Unacceptable Conditions

Grossly bloody or hemolyzed specimens or severe lipemia.


Ambient: Unacceptable; Refrigerated: 2 week; Frozen: 6 months


Qualitative Isoelectric Focusing/Electrophoresis/Quantitative Immunoturbidimetry




1-3 days

Reference Interval

Test Number
Reference Interval
  Albumin, CSF 0-35 mg/dL
  Immunoglobulin G
Age Reference Interval (mg/dL)
0-2 years 242-1108
3-4 years 485-1160
5-9 years 514-1672
10-14 years 581-1652
15-18 years 479-1433
19 years and older 768-1632

  Immunoglobulin G CSF 0.0-6.0 mg/dL
  Albumin, Serum 3500-5200 mg/dL
  Albumin Index 0.0-9.0
  CSF IgG Synthesis Rate Less than or equal to 8.0 mg/d
  CSF IgG/Albumin Ratio 0.09-0.25
  IgG Index 0.28-0.66
  Oligoclonal Bands Number, CSF 0 - 1 Bands

Interpretive Data

To ensure accurate result interpretation, it is recommended that both CSF and serum specimens be collected on the same day. If specimens are not collected within this specified timeframe, it is advised to exercise caution when interpreting the results

Compliance Category



Specimens must be assayed together for interpretation.
A patient is considered positive for CSF oligoclonal bands if there are two or more bands in the CSF immunoglobulin region that are not present in the serum. In order to confirm local production of oligoclonal IgG in CSF, a matched serum sample is required. Oligoclonal bands present in CSF, but not in serum, indicate central nervous system production. Oligoclonal bands are performed using isoelectric focusing and immunofixation.

Hotline History


CPT Codes

83916; 82784 x2; 82040; 82042


Component Test Code* Component Chart Name LOINC
0050200 Albumin, CSF 1746-7
0050350 Immunoglobulin G 2465-3
0050670 Immunoglobulin G CSF 2464-6
0050671 Albumin, Serum 1751-7
0050672 Albumin Index 1756-6
0050675 CSF IgG Synthesis Rate 14116-8
0080095 CSF Oligoclonal Bands 12782-9
0080099 Interpretation 49293-4
0080175 CSF IgG/Albumin Ratio 2470-3
0080180 IgG Index 14117-6
2005461 Oligoclonal Bands Number, CSF 49852-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • CSF Oligoclonal Bands
  • MS Panel
  • MS Profile
  • Multiple Sclerosis Panel
  • Multiple Sclerosis Panel without Myelin Basic Protein
  • Multiple Sclerosis Profile
  • Oligoclonal Banding
Oligoclonal Band Profile