Ordering Recommendation

Preferred test in the workup of multiple sclerosis. Detect unique IgG oligoclonal bands in cerebrospinal fluid (CSF) in conjunction with a matched serum specimen. Calculate CSF IgG index.




Qualitative Isoelectric Focusing/Electrophoresis/Quantitative Immunoturbidimetry




1-3 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

CSF AND serum separator tube or plain red. Serum specimen should be drawn within 48 hours of CSF collection.

Specimen Preparation

Allow serum to clot completely at room temperature. Separate serum from cells ASAP or within 2 hours of collection. Transport 1.5 mL CSF. (Min: 1.0 mL) AND transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.6 mL)

Storage/Transport Temperature


Unacceptable Conditions

Grossly bloody or hemolyzed specimens or severe lipemia.


Ambient: Unacceptable; Refrigerated: 2 week; Frozen: 6 months

Reference Interval

Test Number
Reference Interval
0050350 Immunoglobulin G Effective February 16, 2021
0-2 years: 242-1108 mg/dL            
3-4 years: 485-1160 mg/dL
5-9 years: 514-1672 mg/dL     
10-14 years: 581-1652 mg/dL                   
15-18 years: 479-1433 mg/dL                         
19 years and older : 768-1632 mg/dL

3003485 Immunoglobulin G, CSF 0.0-6.0 mg/dL
0050200 Albumin, CSF 0-35 mg/dL
  Albumin Index 0.0-9.0
  CSF IgG/Albumin Ratio 0.09-0.25
  IgG Index 0.28-0.66
  CSF Oligoclonal Bands Negative
  Interpretation By report
  CSF IgG Synthesis Rate Less than or equal to 8.0 mg/d
  Albumin, Serum 3500-5200 mg/dL
  Oligoclonal Bands Number, CSF 0 - 1 Bands

Interpretive Data

Compliance Category



Specimens must be assayed together for interpretation.
A patient is considered positive for CSF oligoclonal bands if there are two or more bands in the CSF immunoglobulin region that are not present in the serum. In order to confirm local production of oligoclonal IgG in CSF, a matched serum sample is required. Oligoclonal bands present in CSF, but not in serum, indicate central nervous system production. Oligoclonal bands are performed using isoelectric focusing and immunofixation.

Hotline History


CPT Codes

83916; 82784 x2; 82040; 82042


Component Test Code* Component Chart Name LOINC
0050200 Albumin, CSF 1746-7
0050350 Immunoglobulin G 2465-3
0050670 Immunoglobulin G CSF 2464-6
0050671 Albumin, Serum 1751-7
0050672 Albumin Index 1756-6
0050675 CSF IgG Synthesis Rate 14116-8
0080095 CSF Oligoclonal Bands 12782-9
0080099 Interpretation 49293-4
0080175 CSF IgG/Albumin Ratio 2470-3
0080180 IgG Index 14117-6
2005461 Oligoclonal Bands Number, CSF 49852-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • CSF Oligoclonal Bands
  • MS Panel
  • MS Profile
  • Multiple Sclerosis Panel
  • Multiple Sclerosis Panel without Myelin Basic Protein
  • Multiple Sclerosis Profile
  • Oligoclonal Banding
Oligoclonal Band Profile