Ordering Recommendation

Aids in the detection of insulinoma. Do not use to diagnose diabetes mellitus.

Mnemonic

PROINS

Methodology

Quantitative Chemiluminescent Immunoassay

Performed

Tue, Thu

Reported

1-6 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Patient must fast for 12-15 hours prior to collection.

Collect

Serum Separator Tube (SST) or Plain Red. Also acceptable: Lavender (K2EDTA) or Pink (K2EDTA).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube and freeze immediately. (Min: 0.2 mL)

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Grossly hemolyzed specimens.

Remarks
Stability

After separation from cells: Ambient: Unacceptable; Refrigerated: 48 hours; Frozen: 2 months

Reference Interval

Effective May 19, 2014

Age Reference Interval
0-17 years Not established
18 years and older Less than or equal to 8.0 pmol/L

Interpretive Data

Fasting intact proinsulin values above the reference interval indicate a possible insulin secreting pancreatic tumor (insulinoma) in patients with hypoglycemia. Fasting intact proinsulin values range from 3 to 50 pmol/L in patients with untreated type 2 diabetes.

Compliance Category

FDA

Note

Hotline History

N/A

CPT Codes

84206

Components

Component Test Code* Component Chart Name LOINC
0070112 Proinsulin, Intact 10451-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Proinsulin, Plasma
Proinsulin, Intact