0070105
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Renin Activity

RENIN
Example Reports
Abnormal
Normal

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Additional Technical Information

Ordering Recommendation

The combined aldosterone/renin tests are preferred when screening for hyperaldosteronism. Refer to Aldosterone/Renin Activity Ratio (0070073) or Aldosterone and Renin Direct, With Ratio (3005949).

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Blood should be obtained in seated position in the morning without venous stasis (release tourniquet after venipuncture and wait at least 5 seconds before withdrawing blood). If the patient is supine, ensure that the patient is in this position for at least 30 minutes prior to collection.

Collect

Lavender (EDTA) or pink (K2EDTA). Do not collect in refrigerated tubes nor store tubes on ice.

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 2 mL plasma to an ARUP standard transport tube and freeze immediately. (Min: 1.2 mL)
Storage at refrigerated temperatures may cause falsely elevated results. Do not collect in refrigerated tubes. Process blood at room temperature and centrifuge tubes in a nonrefrigerated centrifuge.

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Serum. Specimens collected in citrate, heparin, or oxalate. Hemolyzed specimens.

Remarks
Stability

After separation from cells: Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 1 month

Methodology

Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)

Performed

Sun-Sat

Reported

1-4 days

Reference Interval

Test Number
 Components
 Reference Interval
  Renin Activity
Age
 Supine (ng/mL/hr)
Normal sodium diet
 Upright (ng/mL/hr)
Normal sodium diet
Cord blood 4.0-32.0 Not Available
Newborn (1-7 days) 2.0-35.0 Not Available
1-12 months 2.4-37.0 Not Available
13 months-3 years 1.7-11.2 Not Available
4-5 years 1.0-6.5 Less than or equal to 15
6-10 years 0.5-5.9 Less than or equal to 17
11-15 years 0.5-3.3 Less than or equal to 16
Adult 0.2-1.6 0.5-4.0

Interpretive Data

Plasma renin activity measures enzyme ability to convert angiotensinogen to angiotensin I and is limited by the availability of angiotensinogen. Plasma renin activity is not an accurate indicator of enzyme activity when angiotensinogen is decreased.

Compliance Category

Laboratory Developed Test (LDT)

Note

Refer to the Additional Technical Information for Endocrine Society recommendations for patient preparation, specimen collection, medications for hypertension control during confirmatory testing for primary aldosteronism, and factors that may lead to false-positive or false-negative aldosterone-renin ratio (ARR) results.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
04/20/2026
X
X
01/20/2026
X
N/A

CPT Codes

84244

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Components

Component Test Code* Component Chart Name LOINC
0070105 Renin Activity 2915-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Plasma Renin Activity
  • PRA
  • Renin Activity, Plasma
Renin Activity