Ordering Recommendation

The combined aldosterone/renin tests are preferred when screening for hyperaldosteronism. Refer to Aldosterone/Renin Activity Ratio (0070073) or Aldosterone and Renin, Direct with Ratio (2002582).

Mnemonic
RENIN
Methodology

Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Sun-Sat

Reported

1-3 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation

Collect midmorning after patient has been sitting, standing, or walking for at least 2 hours and seated for 5-15 minutes. Refer to the Additional Technical Information for specific patient preparation recommendations.

Collect

Lavender (EDTA) or Pink (K2EDTA). Do not collect in refrigerated tubes.

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 2 mL plasma to an ARUP Standard Transport Tube and freeze immediately. (Min: 1.2 mL)

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Serum. Specimens collected in citrate, heparin, or oxalate. Hemolyzed specimens.

Remarks
Stability

Ambient: 6 hours; Refrigerated: Unacceptable; Frozen: 1 month

Reference Interval
Adult, normal sodium diet
Children, normal sodium diet, supine:
Children, normal sodium diet, upright:
Supine: 0.2-1.6 ng/mL/hr Newborn (1-7 days): 2.0-35.0 ng/mL/hr 0-3 years: Not Available
Upright: 0.5-4.0 ng/mL/hr Cord blood: 4.0-32.0 ng/mL/hr 4-5 years: Less than or equal to 15 ng/mL/hr
1-12 months: 2.4-37.0 ng/mL/hr 6-10 years: Less than or equal to 17 ng/mL/hr
13 months-3 years:1.7-11.2 ng/mL/hr 11-15 years: Less than or equal to 16 ng/mL/hr
4-5 years:1.0-6.5 ng/mL/hr
6-10 years: 0.5-5.9 ng/mL/hr
11-15 years: 0.5-3.3 ng/mL/hr

Interpretive Data

Plasma renin activity measures enzyme ability to convert angiotensinogen to angiotensin I and is limited by the availability of angiotensinogen.  Plasma renin activity is not an accurate indicator of enzyme activity when angiotensinogen is decreased.

Compliance Category

Laboratory Developed Test (LDT)

Note

Refer to the Additional Technical Information for Endocrine Society recommendations for patient preparation, specimen collection, medications for hypertension control during confirmatory testing for primary aldosteronism, and factors that may lead to false-positive or false-negative aldosterone-renin ratio (ARR) results.

Hotline History
N/A
CPT Codes

84244

Components
Component Test Code* Component Chart Name LOINC
0070105 Renin Activity 2915-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Plasma Renin Activity
  • PRA
  • Renin Activity, Plasma
Renin Activity