Ordering Recommendation

The combined aldosterone/renin tests are preferred when screening for hyperaldosteronism. Refer to Aldosterone/Renin Activity Ratio (0070073) or Aldosterone and Renin Direct, With Ratio (3005949).

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Collect midmorning after patient has been sitting, standing, or walking for at least 2 hours and seated for 5-15 minutes. Refer to the Additional Technical Information for specific patient preparation recommendations.


Lavender (EDTA) or Pink (K2EDTA). Do not collect in refrigerated tubes.

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 2 mL plasma to an ARUP Standard Transport Tube and freeze immediately. (Min: 1.2 mL)

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Serum. Specimens collected in citrate, heparin, or oxalate. Hemolyzed specimens.


Ambient: 6 hours; Refrigerated: Unacceptable; Frozen: 1 month


Quantitative Enzyme-Linked Immunosorbent Assay




1-4 days

Reference Interval

Adult, normal sodium diet
Children, normal sodium diet, supine:
Children, normal sodium diet, upright:
Supine: 0.2-1.6 ng/mL/hr Newborn (1-7 days): 2.0-35.0 ng/mL/hr 0-3 years: Not Available
Upright: 0.5-4.0 ng/mL/hr Cord blood: 4.0-32.0 ng/mL/hr 4-5 years: Less than or equal to 15 ng/mL/hr
1-12 months: 2.4-37.0 ng/mL/hr 6-10 years: Less than or equal to 17 ng/mL/hr
13 months-3 years:1.7-11.2 ng/mL/hr 11-15 years: Less than or equal to 16 ng/mL/hr
4-5 years:1.0-6.5 ng/mL/hr
6-10 years: 0.5-5.9 ng/mL/hr
11-15 years: 0.5-3.3 ng/mL/hr

Interpretive Data

Plasma renin activity measures enzyme ability to convert angiotensinogen to angiotensin I and is limited by the availability of angiotensinogen.  Plasma renin activity is not an accurate indicator of enzyme activity when angiotensinogen is decreased.

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration. This test was performed in a CLIA certified laboratory and is intended for clinical purposes.

Compliance Category

Laboratory Developed Test (LDT)


Refer to the Additional Technical Information for Endocrine Society recommendations for patient preparation, specimen collection, medications for hypertension control during confirmatory testing for primary aldosteronism, and factors that may lead to false-positive or false-negative aldosterone-renin ratio (ARR) results.

Hotline History


CPT Codes



Component Test Code* Component Chart Name LOINC
0070105 Renin Activity 2915-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • Plasma Renin Activity
  • PRA
  • Renin Activity, Plasma
Renin Activity