Ordering Recommendation

A combined IgG and IgM antibody panel is available (refer to Chlamydia Antibody Panel, IgG & IgM by IFA (0065100)). Differentiate between Chlamydophila species (C. psittaci, C. pneumoniae). Because of cross-reactivity, a C. pneumoniae-specific reaction will exhibit titers two-fold or greater than C. trachomatis or C. psittaci serology. Limited value in the diagnosis of most oculogenital (eg, eyes, genitalia) chlamydial infections.

Mnemonic
CHLAM G
Methodology

Semi-Quantitative Indirect Fluorescent Antibody

Performed

Mon-Sat

Reported

1-3 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Plain red or serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer1 mL serum to an ARUP Standard Transport Tube. (Min: 0.15 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens. Mark specimens plainly as acute or convalescent.

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Contaminated, hemolyzed, or hyperlipemic sera.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval

 < 1:64  C. trachomatis IgG. 
< 1:64  C. pneumoniae IgG.
<
1:64  C. psittaci IgG.

Interpretive Data

The Chlamydia antibody test contains both species- and genus-specific antigens, and serological cross-reactions may be seen in both acute and convalescent samples (less than 1:128).  A C. pneumoniae-specific reaction will exhibit titers twofold or greater than titers observed with C. trachomatis or C. psittaci serology.  Any IgG titer may indicate past exposure to that particular species.  IgG titers in recently infected individuals are typically greater than or equal to 1:512.

The Chlamydia microimmunofluorescent assay slides utilize C. psittaci, C. pneumoniae, and nine serotypes of C. trachomatis. The LGV strains of C. trachomatis are not included in this assay.

Compliance Category

Analyte Specific Reagent (ASR)

Note

In adult populations, the prevalence of antibody titers indicative of exposure to the organism ranges from 50-78%.

Hotline History
N/A
CPT Codes

86631 x3

Components
Component Test Code* Component Chart Name LOINC
0065104 C. pneumoniae IgG Titer 6913-8
0065106 C. trachomatis IgG Titer 6919-5
0065107 C. psittaci IgG Titer 6916-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Chlamydia IgG Ab
  • CT IgG Ab
Chlamydia Antibody Panel, IgG by IFA