Tissue Transglutaminase Antibody, IgG

0056009
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Example Reports
Negative
Positive

Ordering Recommendation

• Recommended single screening test for IgA-deficient individuals with suspected celiac disease. (IgA testing recommended to identify IgA deficiency.)
• May aid in monitoring adherence to gluten-free diet in celiac disease confirmed patients.

Mnemonic

TTG G

Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Sun-Sat

Reported

1-2 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Remove serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Plasma. Hemolyzed or severely lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year

Reference Interval

5 U/mL or less Negative
6-9 U/mL Weak Positive
10 U/mL or greater Positive

Interpretive Data

The tTG IgG assay may aid in the diagnosis of gluten-sensitivity enteropathy (i.e., celiac disease, dermatitis herpetiformis) in tTG IgA negative patients with confirmed IgA deficiency.  A negative tTG IgG test alone does not rule out gluten-sensitive enteropathy. 

Compliance Category

FDA

Note

Human recombinant tTG antigen is utilized in this assay

Hotline History

N/A

CPT Codes

83516

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Components

Component Test Code* Component Chart Name LOINC
0056009 Tissue Transglutaminase Antibody,IgG 56537-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Tissue Transglutaminase
  • Transglutaminase
  • tTG
  • tTG IgG
Tissue Transglutaminase Antibody, IgG