Deamidated Gliadin Peptide (DGP) Antibody, IgG
New York DOH Approval Status
Serum separator tube (SST).
Separate serum from cells ASAP or within 2 hours of collection. Transport 1.0 mL serum. (Min: 0.5 mL)
Contaminated, grossly hemolyzed, grossly icteric, or grossly lipemic.
After separation from cells: Ambient: 48 hours; Refrigerated: 1 week; Frozen: 15 days
Semi-Quantitative Particle-Based Multianalyte Technology (PMAT)
|Deamidated Gliadin Peptide (DGP) Ab, IgG||0.00-4.99 FLU|
In individuals with low or deficient IgA, testing for tissue transglutaminase (tTG) and deamidated Gliadin (DGP) antibodies of the IgG isotype is performed. A positive tTG and/or DGP IgG antibody results indicate celiac disease, however, small intestinal biopsy is required to establish a diagnosis due to the lower accuracy of these markers, especially in patients without IgA deficiency.
The most sensitive and specific serologic test for celiac disease diagnosis is tissue transglutaminase (tTG) IgA isotype in individuals who produce sufficient total IgA. For individuals who are IgA deficient, testing for tTG and deamidated gliadin (DGP), IgG antibodies is recommended.
Preferred initial screening test for celiac disease diagnosis is the reflexive cascade (ARUP test code 3016817).
While ordering for celiac disease diagnosis, all serology tests should be performed while the patient is on a gluten-containing diet. Upon initiation of gluten-free diet, antibody titers decline in the treatment-responsive patients and the timeframe to normalize varies by case. If serology is negative and suspicion for celiac disease is strong, intestinal biopsy may still be warranted for establishing diagnosis.
|Component Test Code*||Component Chart Name||LOINC|
|0051359||Deamidated Gliadin Peptide (DGP) Ab, IgG||63459-2|
- Celiac Disease Antibodies
- Deamidated Gliadin Antibodies (DGP)
- Deaminated Gliadin Peptide Antibodies
- DGP Ab
- DGP IgG