Ordering Recommendation

Preferred testing for herpes simplex virus (HSV) when exposure to HSV is suspected.

May be useful in identifying a subclinical HSV infection. If results are positive for HSV type 1/2 combined antibodies but negative for both type-specific antibodies, follow-up testing at least one month later is recommended because glycoprotein antibodies may require 3-6 months to form; refer to Herpes Simplex Type 1 and Type 2 Glycoprotein G-Specific Antibodies, IgG by CIA (0051152).

Mnemonic

HERPR PAN2

Methodology

Semi-Quantitative Chemiluminescent Immunoassay

Performed

Sun-Sat

Reported

1-2 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of acute specimens. Mark specimens plainly as "acute" or "convalescent."

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Plasma or urine. Contaminated, heat-inactivated, hemolyzed, or severely lipemic specimens.

Remarks
Stability

Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year

Reference Interval

Interpretive Data




Component Interpretation
Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgG by Chemiluminescent Immunoassay 0.89 IV or less: Not Detected.
0.90-1.09 IV: Indeterminate - Repeat testing in 10-14 days may be helpful.
1.10 IV or greater: Detected.

Compliance Category

FDA

Note

If HSV 1 and/or 2 IgG is 1.10 IV or greater, then HSV 1 gG-Specific IgG and HSV 2 gG-Specific IgG will be added. Additional charges apply.

Hotline History

N/A

CPT Codes

86694; if reflexed, add 86695; 86696

Components

Component Test Code* Component Chart Name LOINC
0050286 HSV Type 1/2 Combined Ab, IgG 27948-9
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • glycoprotein type-specific reactivity
  • Herpes Simplex Antibodies, IgG
  • Herpes Simplex Serology, Serum HSV 1,2
  • HerpeSelect
  • HSV
  • HSV 1, 2 IgG
  • HSV 1,2
  • HSV 1,2 glycoprotein
  • HSV glycoprotein G
  • HSV glycoprotein G-based type-specific serology
Herpes Simplex Virus Type 1 and/or 2 Antibodies, IgG with Reflex to Type 1 and 2 Glycoprotein G-Specific Ab, IgG