Ordering Recommendation

In the absence of active lesions, this is the preferred serology test for diagnosing herpes simplex viral infection.

Mnemonic
HERP PAN 2
Methodology

Semi-Quantitative Chemiluminescent Immunoassay

Performed

Sun-Sat

Reported

1-2 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimen. Mark specimens plainly as "acute" or "convalescent."

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Plasma or urine. Contaminated, heat-inactivated, hemolyzed, or lipemic specimens.

Remarks
Stability

Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year

Reference Interval
Test Number
Components
Reference Interval
0050292 Herpes Simplex Virus Type 1 Glycoprotein G-Specific Antibody, IgG by CIA
Effective February 18, 2020
0.89 IV or less Negative - No significant level of detectable IgG antibody to HSV type 1 glycoprotein G.
0.90-1.09 IV Equivocal - Questionable presence of IgG antibody to HSV type 1 glycoprotein G. Repeat testing in 10-14 days may be helpful.
1.10 IV or greater Positive - IgG antibody to HSV type 1 glycoprotein G detected, which may indicate a current or past HSV infection.

0050294 Herpes Simplex Virus Type 2 Glycoprotein G-Specific Antibody, IgG by CIA
Effective February 18, 2020
0.89 IV or less Negative - No significant level of detectable IgG antibody to HSV type 2 glycoprotein G.
0.90-1.09 IV Equivocal - Questionable presence of IgG antibody to HSV type 2 glycoprotein G.  Repeat testing in 10-14 days may be helpful.
1.10 IV or greater Positive - IgG antibody to HSV type 2 glycoprotein G detected, which may indicate a current or past HSV infection.

Interpretive Data

Individuals infected with HSV may not exhibit detectable IgG antibody to type-specific HSV antigens 1 and 2 in the early stages of infection. Detection of antibody presence in these cases may only be possible using a non-type specific screening test.

Compliance Category

FDA

Note

For CSF, refer to Herpes Simplex Virus Type 1 Glycoprotein G-Specific Antibody, IgG by ELISA, CSF (ARUP test code 0050379) and Herpes Simplex Virus Type 2 Glycoprotein G-Specific Antibody, IgG by ELISA, CSF (ARUP test code 0050359).

Hotline History
N/A
CPT Codes

86695; 86696

Components
Component Test Code* Component Chart Name LOINC
0050292 HSV 1 Glycoprotein G Ab, IgG 42337-6
0050294 HSV 2 Glycoprotein G Antibody, IgG 42338-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • HSV
  • HSV glycoprotein G type 1 and 2
  • HSV typing 1 and 2
Herpes Simplex Type 1 and Type 2 Glycoprotein G-Specific Antibodies, IgG by CIA