Ordering Recommendation

May be helpful in evaluating for autoimmune liver disease. For a more comprehensive reflex panel, refer to Autoimmune Liver Disease Reflexive Panel (3002479).

Mnemonic
SMA R
Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Semi-Quantitative Indirect Fluorescent Antibody

Performed

Sun-Sat

Reported

1-5 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Serum Separator Tube (SST).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube.(Min: 0.25 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Plasma. Contaminated, heat-inactivated, hemolyzed, or lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year

Reference Interval
Test Number
Components
Reference Interval
  F-Actin (Smooth Muscle) Ab, IgG by ELISA
19 Units or less Negative
20-30 Units Weak Positive - Suggest repeat testing in two to three weeks with fresh specimen.
31 Units or greater Positive - Suggestive of autoimmune hepatitis or chronic active hepatitis.

0051244 Smooth Muscle Antibody, IgG Titer
Less than 1:20 Negative - No Antibody detected.
1:20-1:80 Weak Positive - Suggest repeat testing in two to three weeks with fresh specimen.
1:160 or greater Positive - Suggestive of autoimmune hepatitis or chronic active hepatitis.

Interpretive Data

Refer to report.

No compliance statements are in use for this test.

Note

In viral hepatitis the titers are generally less than 1:80 and are transient. The titers in primary biliary cirrhosis are also low, ranging from 1:20 to 1:40.

If F-Actin is 20 Units or greater, then Smooth Muscle Ab, IgG IFA titer will be added. Additional charges apply

Hotline History
N/A
CPT Codes

83516; if reflexed, add 86256

Components
Component Test Code* Component Chart Name LOINC
0055248 F-Actin (Smooth Muscle) Ab, IgG by ELISA 44706-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • Actin Antibody
  • Actin Antibody Reflexive Panel
  • Anti-Smooth Muscle Antibody
  • ASMA
  • ASMA Reflexive Panel
  • F-Actin Antibody
  • F-Actin Antibody Panel
  • SMA
  • SMA IgG
  • SMA IgG Ab
  • SMA Reflexive Panel
  • Smooth Muscle Antibodies
  • Soft-SMA
F-Actin (Smooth Muscle) Antibody, IgG by ELISA with Reflex to Smooth Muscle Antibody, IgG Titer