Autoimmune Liver Disease Reflexive Panel

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Additional Technical Information

Ordering Recommendation

Recommended initial screening panel when autoimmune liver disease is strongly suspected. If negative, less frequently occurring autoantibody tests maybe ordered based on patient’s clinical presentation and history.

Mnemonic

LIVER PAN

Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay/Semi-Quantitative Indirect Fluorescent Antibody

Performed

Sun-Sat

Reported

1-8 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Serum Separator Tube (SST).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Non-serum, heat-inactivated, contaminated, grossly icteric, severely lipemic, grossly hemolyzed specimens or inclusion of fibrin clot.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval

Test Number
 Components
 Reference Interval
0050065 Mitochondrial M2 Antibody, IgG (ELISA)
20.0 Units or less Negative
20.1-24.9 Units Equivocal
25.0 Units or greater Positive

0051174 F-Actin (Smooth Muscle) Antibody, IgG by ELISA with Reflex to Smooth Muscle Antibody, IgG Titer
Test Number
 Components
 Reference Interval
  F-Actin (Smooth Muscle) Ab, IgG by ELISA Refer to report
0051244 Smooth Muscle Antibody, IgG Titer Refer to report

0055235 Soluble Liver Antigen Antibody, IgG
0.0-20.0 U Negative
20.1-24.9 U Equivocal
Greater than or equal to 25.0 U Positive

0055241 Liver-Kidney Microsome - 1 Antibody, IgG
0.0-20.0 U Negative
20.1-24.9 U Equivocal
25.0 U or greater Positive

3000082 Antinuclear Antibody (ANA) with HEp-2 Substrate, IgG by IFA Less than 1:80

Interpretive Data

Refer to report.

Compliance Category

FDA

Note

If F-Actin, IgG by ELISA is 20 Units or greater, then Smooth Muscle Antibody (SMA), IgG by IFA titer will be added. Additional charges apply.
ANA identified by indirect fluorescence assay (IFA) using HEp-2 substrate and IgG-specific conjugate at a screening dilution of 1:80. Positive nuclear patterns reported include homogeneous, speckled, centromere, nucleolar, or nuclear dots. Positive cytoplasmic patterns reported include reticular/AMA, discrete/GW body-like, polar/golgi-like, rods and rings, or cytoplasmic speckled patterns. All positive results are reported with endpoint titers at no additional charge.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
08/17/2020
X
X
05/18/2020
X
N/A

CPT Codes

86039, 86376, 83516 x3; if reflexed, add 86256

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Components

Component Test Code* Component Chart Name LOINC
0050065 Mitochondrial (M2) Antibody, IgG 14251-3
0055235 Soluble Liver Antigen Antibody, IgG 38420-6
0055241 Liver-Kid Microsome-1 Ab, IgG by ELISA 47318-1
0055248 F-Actin (Smooth Muscle) Ab, IgG by ELISA 44706-0
3000090 Antinuclear Antibody (ANA), HEp-2, IgG 21424-7
3000096 ANA Interpretive Comment 49311-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

Autoimmune Liver Disease Reflexive Panel