Glomerular Basement Membrane Antibody, IgG by Multiplex Bead Assay

0051000
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Example Reports
Negative
Positive

Ordering Recommendation

May be useful in detecting glomerular basement membrane (GBM) antibodies. Combined use of IFA Glomerular Basement Membrane Antibody, IgG by Multiplex Bead Assay and IFA (2008403) may improve diagnostic sensitivity for disease. If positive, may be useful for monitoring treatment response.

Mnemonic

GBM-G ELIS

Methodology

Semi-Quantitative Multiplex Bead Assay

Performed

Sun-Sat

Reported

1-2 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.15 mL) 

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions
Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval

19 AU/mL or less Negative
20-25 AU/mL Equivocal
26 AU/mL or greater Positive

Interpretive Data

The presence of anti-glomerular basement membrane (GBM) antibodies by Multiplex Bead Assay, may aid in the diagnosis of Goodpasture syndrome.  False positive results may occur due to reactivity against other chains of type IV collagen.  If Multiplex Bead Assay is negative but there is strong suspicion for disease, renal biopsy may be indicated.  A renal biopsy may also be essential in suspected Goodpasture disease with renal involvement, allowing diagnostic confirmation and assessment of renal prognosis.

Compliance Category

FDA

Note

Hotline History

N/A

CPT Codes

83516

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Components

Component Test Code* Component Chart Name LOINC
0051000 GBM Ab, IgG by Multiplex Bead Assay 44446-3
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Anti-GBM Antibody
  • Anti-GBM Antibody-IgG
  • Anti-Glomerular Basement Membrane Antibody
  • Antiglomerular Basement Membrane Antibody-IgG
  • Basement Membrane Antibody
  • Basement Membrane, Glomerular Antibody
  • GBM Antibody
  • Glomerular Anti-Basement Membrane
Glomerular Basement Membrane Antibody, IgG by Multiplex Bead Assay