May be useful in detecting glomerular basement membrane (GBM) antibodies. Combined use of IFA Glomerular Basement Membrane Antibody, IgG by Multiplex Bead Assay and IFA (2008403) may improve diagnostic sensitivity for disease. If positive, may be useful for monitoring treatment response.
Semi-Quantitative Multiplex Bead Assay
Serum separator tube.
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.15 mL)
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
|19 AU/mL or less||Negative|
|26 AU/mL or greater||Positive|
The presence of anti-glomerular basement membrane (GBM) antibodies by Multiplex Bead Assay, may aid in the diagnosis of Goodpasture syndrome. False positive results may occur due to reactivity against other chains of type IV collagen. If Multiplex Bead Assay is negative but there is strong suspicion for disease, renal biopsy may be indicated. A renal biopsy may also be essential in suspected Goodpasture disease with renal involvement, allowing diagnostic confirmation and assessment of renal prognosis.
|Component Test Code*||Component Chart Name||LOINC|
|0051000||GBM Ab, IgG by Multiplex Bead Assay||44446-3|
- Anti-GBM Antibody
- Anti-GBM Antibody-IgG
- Anti-Glomerular Basement Membrane Antibody
- Antiglomerular Basement Membrane Antibody-IgG
- Basement Membrane Antibody
- Basement Membrane, Glomerular Antibody
- GBM Antibody
- Glomerular Anti-Basement Membrane