Preferred panel for detecting glomerular basement membrane (GBM) antibodies in suspected or established anti-GBM disease. If positive, may be useful for monitoring treatment response.
Semi-Quantitative Multiplex Bead Assay/Qualitative Indirect Fluorescent Antibody
Serum separator tube.
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
When present, IgG antibody to glomerular basement membrane (GBM) antigen detected by either indirect fluorescent antibody (IFA) or multiplex bead assay helps support a diagnosis of Goodpasture syndrome. However, the combined result of both assays performed during initial evaluation improves the diagnostic sensitivity for disease. A positive result in one or both assays should be confirmed by renal biopsy.
Laboratory Developed Test (LDT)
|Component Test Code*||Component Chart Name||LOINC|
|0049191||GBM Antibody, IgG by IFA||29994-1|
|0051000||GBM Ab, IgG by Multiplex Bead Assay||44446-3|
- Anti-GBM Antibody-IgG
- Antiglomerular Basement Membrane Antibody-IgG
- Basement Membrane Antibody
- Basement Membrane, Glomerular Antibody
- GBM Antibody
- Glomerular Anti-Basement Membrane