Ordering Recommendation
Recommended for the differential diagnosis of SLE and Sjogren syndrome. Preferred panel contains SSA 52, SSA 60, and SSB; refer to Extractable Nuclear Antigen Antibodies (SSA 52, SSA 60, and SSB) (0050791).
Mnemonic
Methodology
Semi-Quantitative Multiplex Bead Assay
Performed
Sun-Sat
Reported
1-2 days
New York DOH Approval Status
Specimen Required
Serum separator tube.
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.2 mL)
Refrigerated.
Plasma or other body fluids. Contaminated, hemolyzed, or severely lipemic specimens.
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Reference Interval
29 AU/mL or less | Negative |
30-40 AU/mL | Equivocal |
41 AU/mL or greater | Positive |
Interpretive Data
SSB (La) antibody is seen in 50-60% of Sjögren syndrome cases and is specific if it is the only ENA antibody present. Fifteen-25% of patients with systemic lupus erythematosus (SLE) and 5-10% of patients with progressive systemic sclerosis (PSS) also have this antibody.
FDA
Note
Hotline History
CPT Codes
86235
Components
Component Test Code* | Component Chart Name | LOINC |
---|---|---|
0050692 | SSB (La) (ENA) Antibody, IgG | 29965-1 |
Aliases
- anti-Sjögren Syndrome B
- anti-SSB
- Anti-SSB (La) (ENA) Antibody
- Sjogren's Antibody
- SSB (La)