Ordering Recommendation

Recommended for the differential diagnosis of SLE and Sjogren syndrome. Preferred panel contains SSA 52, SSA 60, and SSB; refer to Extractable Nuclear Antigen Antibodies (SSA 52, SSA 60, and SSB) (0050791).

Mnemonic

SSB

Methodology

Semi-Quantitative Multiplex Bead Assay

Performed

Sun-Sat

Reported

1-2 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.2 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Plasma or other body fluids. Contaminated, hemolyzed, or severely lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval

29 AU/mL or less Negative
30-40 AU/mL Equivocal
41 AU/mL or greater Positive

Interpretive Data

SSB (La) antibody is seen in 50-60% of Sjögren syndrome cases and is specific if it is the only ENA antibody present. Fifteen-25% of patients with systemic lupus erythematosus (SLE) and 5-10% of patients with progressive systemic sclerosis (PSS) also have this antibody.

Compliance Category

FDA

Note

Hotline History

N/A

CPT Codes

86235

Components

Component Test Code* Component Chart Name LOINC
0050692 SSB (La) (ENA) Antibody, IgG 29965-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • anti-Sjögren Syndrome B
  • anti-SSB
  • Anti-SSB (La) (ENA) Antibody
  • Sjogren's Antibody
  • SSB (La)
SSB (La) (ENA) Antibody, IgG