0050791
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Extractable Nuclear Antigen Antibodies (SSA 52, SSA 60, and SSB)

SSA/SSB
Example Reports
Negative
Positive

Ordering Recommendation

Use for differential evaluation of patients with systemic lupus erythematosus (SLE), Sjögren syndrome, polymyositis/dermatomyositis, and/or other tissue diseases or overlapping syndromes.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Plasma or other body fluids.  Contaminated, hemolyzed, or severely lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Methodology

Semi-Quantitative Multiplex Bead Assay

Performed

Sun-Sat

Reported

1-2 days

Reference Interval

Test Number
 Components
 Reference Interval
  SSA-52 (Ro52) (ENA) Antibody, IgG 40 AU/mL or less
  SSB (La) (ENA) Antibody, IgG 40 AU/mL or less
  SSA-60 (Ro60) (ENA) Antibody, IgG 40 AU/mL or less

Interpretive Data




Component
 Interpretation
SSA-52 (Ro52) (ENA) Antibody, IgG 29 AU/mL or Less          Negative
30-40 AU/mL                   Equivocal
41 AU/mL or greater      Positive
SSA-60 (Ro60) (ENA) Antibody, IgG 29 AU/mL or Less          Negative
30-40 AU/mL                   Equivocal
41 AU/mL or greater      Positive
SSB (La) (ENA) Antibody, IgG 29 AU/mL or less          Negative
30-40 AU/mL                 Equivocal
41 AU/mL or greater    Positive

Compliance Category

FDA

Note

Hotline History

N/A

CPT Codes

86235 x3

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Components

Component Test Code* Component Chart Name LOINC
0050691 SSA-52 (Ro52) (ENA) Antibody, IgG 31625-7
0050692 SSB (La) (ENA) Antibody, IgG 29965-1
2012055 SSA-60 (Ro60) (ENA) Antibody, IgG 53019-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Ro Ab
  • Smith (ENA) Antibody, IgG
  • Anti-ENA Anti-Ribonuclear Protein
  • SSA (Ro) (ENA) Antibody, IgG
  • SSA Ro
  • SSB (La) (ENA) Antibody, IgG
  • SSB LA
Extractable Nuclear Antigen Antibodies (SSA 52, SSA 60, and SSB)