Extractable Nuclear Antigen Antibodies (SSA 52, SSA 60, and SSB)

0050791
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Example Reports
Negative
Positive

Ordering Recommendation

Use for differential evaluation of patients with systemic lupus erythematosus (SLE), Sjögren syndrome, polymyositis/dermatomyositis, and/or other tissue diseases or overlapping syndromes.

Mnemonic

SSA/SSB

Methodology

Semi-Quantitative Multiplex Bead Assay

Performed

Sun-Sat

Reported

1-2 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Plasma or other body fluids.  Contaminated, hemolyzed, or severely lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval

Test Number
 Components
 Reference Interval
  SSA-52 (Ro52) (ENA) Antibody, IgG 40 AU/mL or less
  SSB (La) (ENA) Antibody, IgG 40 AU/mL or less
  SSA-60 (Ro60) (ENA) Antibody, IgG 40 AU/mL or less

Interpretive Data




Component
 Interpretation
SSA-52 (Ro52) (ENA) Antibody, IgG 29 AU/mL or Less          Negative
30-40 AU/mL                   Equivocal
41 AU/mL or greater      Positive
SSA-60 (Ro60) (ENA) Antibody, IgG 29 AU/mL or Less          Negative
30-40 AU/mL                   Equivocal
41 AU/mL or greater      Positive
SSB (La) (ENA) Antibody, IgG 29 AU/mL or less          Negative
30-40 AU/mL                 Equivocal
41 AU/mL or greater    Positive

Compliance Category

FDA

Note

Hotline History

N/A

CPT Codes

86235 x3

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Components

Component Test Code* Component Chart Name LOINC
0050691 SSA-52 (Ro52) (ENA) Antibody, IgG 31625-7
0050692 SSB (La) (ENA) Antibody, IgG 29965-1
2012055 SSA-60 (Ro60) (ENA) Antibody, IgG 53019-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Anti-ENA Anti-Ribonuclear Protein
  • Ro Ab
  • Smith (ENA) Antibody, IgG
  • SSA (Ro) (ENA) Antibody, IgG
  • SSA Ro
  • SSB (La) (ENA) Antibody, IgG
  • SSB LA
Extractable Nuclear Antigen Antibodies (SSA 52, SSA 60, and SSB)