Immune Complex Panel

0050667
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Example Reports
Abnormal
Normal
Ordering Recommendation

Detect circulating immune complexes.

Mnemonic
C1Q/RAJI
Methodology

Quantitative Flow Cytometry/Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Tue

Reported

2-9 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Plain red or serum separator tube (SST).

Specimen Preparation

Allow complete clotting of red blood cells (up to 1 hour), then separate serum from cells within 30 minutes and freeze immediately. Transfer TWO (2) 1 mL aliquots of serum to individual ARUP Standard Transport Tubes. (Min: 0.5 mL/aliquot)

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Non-frozen specimens. Specimens exposed to repeated freeze/thaw cycles.

Remarks
Stability

Raji: Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 30 days
C1q: (After separation from cells): Ambient: 2 hours; Refrigerated: Unacceptable; Frozen: 2 weeks (avoid repeated freeze/thaw cycles)

Reference Interval
Available Separately
 Components
 Reference Interval
0050301 C1q Binding Assay Effective February 19, 2019
Less than or equal to 3.9 µg Eq/mL
0050302 Raji Cell Immune Complex Assay By report

Interpretive Data

Less than or equal to 3.9 µg Eq/mL is considered negative for circulating complement binding immune complexes. Circulating immune complexes may be found without any evident pathology and positive results do not necessarily implicate the immune complex in a disease process. Many autoimmune disorders, chronic infections and malignancies are associated with circulating immune complexes.  Quantitation of immune complexes assists in staging immunologic disorders.

Compliance Category

Laboratory Developed Test (LDT)

Note

Immune complexes bind to Raji Cells via their complement receptors. The immunoglobulin portion of the immune complex is then detected by flow cytometry with anti-human IgG-FITC.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
02/19/2019
X
X
X
N/A
CPT Codes

86332 x2

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Components
Component Test Code* Component Chart Name LOINC
0050301 C1q Binding Assay 27831-7
0050302 Raji Cell Immune Complex Assay 10864-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • C1q Immune Complexes
  • C3d and C1q binding
  • CIC
  • Circulating Immune Complex Panel
Immune Complex Panel