Ordering Recommendation

Use to detect circulating immune complexes.

Mnemonic

CIC-C3,C1Q

Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Saturday, Monday, Thursday

Reported

2-9 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Plain red or serum separator tube (SST).

Specimen Preparation

Allow complete clotting of red blood cells (up to 1 hour), then separate serum from cells within 30 minutes and freeze immediately. Transfer TWO (2) 1 mL aliquots of serum to individual ARUP Standard Transport Tubes. (Min: 0.5 mL/aliquot)

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Non-frozen specimens. Specimens exposed to repeated freeze/thaw cycles. Grossly hemolyzed, lipemic, and icteric specimens.

Remarks
Stability

Ambient: Unacceptable; Refrigerated: Unacceptable; Frozen: 2 weeks

Reference Interval

Test Number
Components
Reference Interval
0050301 Circulating Immune Complex, C1q Binding Effective February 19, 2019
Less than or equal to 3.9 µg Eq/mL
3004431 Circulating Immune Complex, C3 fragments Less than or equal to 15 µg Eq/mL

Interpretive Data

Many autoimmune disorders, chronic infections, and malignancies are associated with circulating immune complexes. Quantitation of immune complexes assists in staging immunologic disorders. Detection of circulating immune complexes is not essential to any specific diagnosis. Circulating immune complexes may be found without any evident pathology and positive results do not necessarily implicate immune complex-related disease process. Values between 15 and 20 ug Eq/mL are considered equivocal for the Circulating Immune Complex, C3 fragments assay. Repeat testing using a new specimen is recommended, if clinically indicated.

Compliance Category

FDA

Note

Hotline History

N/A

CPT Codes

86332 x2

Components

Component Test Code* Component Chart Name LOINC
0050301 Circulating Immune Complex, C1q Binding 27831-7
3004432 Circulating Immune Complex, C3 fragments 5228-2
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • C1q binding Immune Complexes
  • C1q binding; CIC
  • C3 fragment containing immune complexes
  • CIC-Raji Cell Replacement assay
  • Circulating Immune Complex Panel
Circulating Immune Complex Panel