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Histoplasma Antibodies by CF
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Ordering Recommendation
Not recommended as a stand-alone test. Refer to Histoplasma Antibodies by CF & ID (0050627).
Mnemonic
Methodology
Semi-Quantitative Complement Fixation
Performed
Sun-Sat
Reported
2-5 days
New York DOH Approval Status
Specimen Required
Serum separator tube.
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.4 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of acute specimens. Mark specimens plainly as acute or convalescent.
Refrigerated.
Contaminated or severely lipemic specimens.
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Reference Interval
| Test Number |
Components |
Reference Interval |
|---|---|---|
| Histoplasma Mycelia, CF | Less than 1:8 | |
| Histoplasma Yeast, CF | Less than 1:8 |
Interpretive Data
An antibody titer greater than or equal to 1:8 is generally considered presumptive evidence of histoplasmosis. Greater than 1:32 or rising titers indicate strong presumptive evidence of histoplasmosis.
Yeast phase is regarded as more sensitive. Approximately 90-95 percent of cases have positive titers to one or both antigens. Titers to mycelial antigen are higher in chronic infection. Cross-reactions, usually at lower titers, may occur with other fungal disease. Rising titers suggest progression of infection. Skin tests in individuals previously exposed may cause titer elevation in 17-20 percent of cases.
FDA
Note
Negative fungal serology does not rule out the possibility of current infection.
Hotline History
Hotline History
CPT Codes
86698 x2
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0050330 | Histoplasma Mycelia, CF | 20573-2 |
| 0050335 | Histoplasma Yeast, CF | 20574-0 |
Aliases
- H. Mycelia Ab
- Histoplasma Yeast Ab
- Histoplasmosis Antibody
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