Histoplasma Antibodies by CF

0050625
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Example Reports
Detected
None Detected

Ordering Recommendation

Not recommended as a stand-alone test. Refer to Histoplasma Antibodies by CF & ID (0050627).

Mnemonic

HISTO

Methodology

Semi-Quantitative Complement Fixation

Performed

Sun-Sat

Reported

1-3 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.4 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of acute specimens. Mark specimens plainly as acute or convalescent.

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Contaminated or severely lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval

Test Number
 Components
 Reference Interval
  Histoplasma Mycelia, CF Less than 1:8
  Histoplasma Yeast, CF Less than 1:8

Interpretive Data

An antibody titer greater than or equal to 1:8  is generally considered presumptive evidence of histoplasmosis. Greater than 1:32 or rising titers indicate strong presumptive evidence of histoplasmosis.

Yeast phase is regarded as more sensitive. Approximately 90-95 percent of cases have positive titers to one or both antigens. Titers to mycelial antigen are higher in chronic infection. Cross-reactions, usually at lower titers, may occur with other fungal disease. Rising titers suggest progression of infection. Skin tests in individuals previously exposed may cause titer elevation in 17-20 percent of cases.

Compliance Category

Standard

Note

Negative fungal serology does not rule out the possibility of current infection.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
08/17/2020
X
N/A

CPT Codes

86698 x2

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Components

Component Test Code* Component Chart Name LOINC
0050330 Histoplasma Mycelia, CF 20573-2
0050335 Histoplasma Yeast, CF 20574-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • H. Mycelia Ab
  • Histoplasma Yeast Ab
  • Histoplasmosis Antibody
Histoplasma Antibodies by CF