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Histoplasma Antibodies by Complement Fixation
Ordering Recommendation
Aids in the diagnosis of histoplasmosis. Not recommended as a standalone test. For more complete serologic testing, immunodiffusion should be performed in parallel with complement fixation; refer to Histoplasma Antibodies by Complement Fixation and Immunodiffusion (0050627).
New York DOH Approval Status
Specimen Required
Serum separator tube.
Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.4 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of acute specimens. Mark specimens plainly as "acute" or "convalescent."
Refrigerated.
Contaminated, hemolyzed, or severely lipemic specimens.
After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Methodology
Semi-Quantitative Complement Fixation
Performed
Sun-Sat
Reported
2-5 days
Reference Interval
| Test Number |
Components |
Reference Interval |
|---|---|---|
| Histoplasma Mycelia Antibodies by CF | Less than 1:8 | |
| Histoplasma Yeast Antibodies by CF | Less than 1:8 |
Interpretive Data
A titer of 1:8 or greater is generally considered presumptive evidence of histoplasmosis. A titer of 1:32 or greater or rising titers indicate strong presumptive evidence of histoplasmosis. Cross-reactions, usually at lower titers, may occur with other fungal diseases.
FDA
Note
This complement fixation test detects total antibodies to mycelial and yeast antigens of Histoplasma.
Hotline History
CPT Codes
86698 x2
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0050330 | Histoplasma Mycelia Antibodies by CF | 20573-2 |
| 0050335 | Histoplasma Yeast Antibodies by CF | 20574-0 |
Aliases
- Histoplasma capsulatum
- Histoplasmosis
- Precipitin
