Histoplasma Antibodies by Complement Fixation

0050625
copy
 

Copy Utility


emailprint
Example Reports
Detected
None Detected

Ordering Recommendation

Aids in the diagnosis of histoplasmosis. Not recommended as a standalone test. For more complete serologic testing, immunodiffusion should be performed in parallel with complement fixation; refer to Histoplasma Antibodies by Complement Fixation and Immunodiffusion (0050627).

Mnemonic

HISTO

Methodology

Semi-Quantitative Complement Fixation

Performed

Sun-Sat

Reported

2-5 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.4 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of acute specimens. Mark specimens plainly as "acute" or "convalescent."

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Contaminated, hemolyzed, or severely lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval

Test Number
 Components
 Reference Interval
  Histoplasma Mycelia Antibodies by CF Less than 1:8
  Histoplasma Yeast Antibodies by CF Less than 1:8

Interpretive Data

A titer of 1:8 or greater is generally considered presumptive evidence of histoplasmosis. A titer of 1:32 or greater or rising titers indicate strong presumptive evidence of histoplasmosis. Cross-reactions, usually at lower titers, may occur with other fungal diseases.

Compliance Category

FDA

Note

This complement fixation test detects total antibodies to mycelial and yeast antigens of Histoplasma.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
08/15/2022
X
X
X
X
X
08/16/2021
X
N/A

CPT Codes

86698 x2

Are you an ARUP Client? Click here for your pricing.

Components

Component Test Code* Component Chart Name LOINC
0050330 Histoplasma Mycelia Antibodies by CF 20573-2
0050335 Histoplasma Yeast Antibodies by CF 20574-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Histoplasma capsulatum
  • Histoplasmosis
  • Precipitin
Histoplasma Antibodies by Complement Fixation