Hemoglobin Evaluation with Reflex to Electrophoresis and/or RBC Solubility

0050610
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Example Reports
Abnormal AC
Abnormal E
Abnormal S
Normal

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Additional Technical Information

Ordering Recommendation

Effective test for screening and follow up of individuals with known hemoglobinopathies.

Mnemonic

HGBEL

Methodology

High Performance Liquid Chromatography (HPLC) /Electrophoresis/RBC Solubility

Performed

Sun-Sat

Reported

1-5 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Lavender (EDTA) or pink (K2EDTA).

Specimen Preparation

Transport 5 mL whole blood. (Min: 0.2 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Frozen or room temperature specimens.

Remarks
Stability

Ambient: Unacceptable; Refrigerated: 1 week; Frozen: Unacceptable

Reference Interval

Effective August 19, 2013

Age-Defined Normal Hemoglobin Reference Intervals
Age
 Hb A Percent
 Hb A2 Percent
 Hb F Percent
 Hb S Percent
 Hb C Percent
 Hb E Percent
 Hb Other Percent
0-1 month
2 months
3 months
4 months
5 months
6-8 months
9-12 months
13-23 months
2 years and older		 7.6-54.8
14.7-70.1
26.6-81.8
43.0-89.5
60.8-94.0
78.2-96.6
86.1-97.2
85.1-97.7
95.0-97.9		 0.0-1.4
0.0-2.0
0.1-2.6
0.8-3.0
1.5-3.3
1.8-3.5
1.9-3.5
1.9-3.5
2.0-3.5		 45.8-91.7
32.7-85.2
14.5-73.7
4.2-56.9
1.0-38.1
0.9-19.4
0.6-11.6
0.0-8.5
0.0-2.1		 0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0		 0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0		 0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0		 0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0

Interpretive Data



Compliance Category

FDA

Note

If abnormal peaks suggestive of a hemoglobin variant are detected, then RBC Solubility and/or Capillary
Electrophoresis will be added to aid in confirmation and identification of the variant. Additional charges apply.
Quantitation of hemoglobin is recommended for a definitive diagnosis in infants 1 year and older.

Additional testing of detected hemoglobin variants may increase turnaround time up to 10 days.

Hotline History

N/A

CPT Codes

83021; if reflexed, add 83020; 85660

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Components

Component Test Code* Component Chart Name LOINC
0050295 Hemoglobin A 4547-6
0050300 Hemoglobin A2 4551-8
0050305 Hemoglobin C 4563-3
0050310 Hemoglobin E 4575-7
0050315 Hemoglobin F 4576-5
0050320 Hemoglobin - Other 48343-8
0050325 Hemoglobin S 4625-0
0050611 Hemoglobin Evaluation 21026-0
0081270 Sickle Cell Solubility 6864-3
2008793 Hemoglobin, Capillary Electrophoresis 13514-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Evaluation, Hemoglobin
  • Fetal Hemoglobin (Hemoglobin F)
  • Hb
  • Hb ELP
  • Hb IEF
  • Hemoglobin Evaluation
  • Hemoglobin Fractionation
  • Hemoglobinopathy Fractionation Profile
  • Hgb
  • Sickle Cell Anemia Screen
  • Sickle Cell Disease
  • Sickle Cell Screen
Hemoglobin Evaluation with Reflex to Electrophoresis and/or RBC Solubility