Ordering Recommendation

May be useful for the diagnosis of Crohn disease. Test by itself is not diagnostic and should be used in conjunction with other parameters to confirm disease. Inflammatory Bowel Disease Differentiation Panel (2013270) is the preferred test.

Mnemonic
SC PAN
Methodology

Semi-Quantitative Enzyme-Linked Immunosorbent Assay

Performed

Sun-Sat

Reported

1-2 days

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Serum separator tube.

Specimen Preparation

Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Contaminated, heat-inactivated, hemolyzed, or severely lipemic specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval
Test Number
Components
Reference Interval
  S. cerevisiae Antibody, IgG
20.0 Units or less Negative
20.1-24.9 Units Equivocal
25.0 Units or greater Positive

  S. cerevisiae Antibody, IgA
20.0 Units or less Negative
20.1-24.9 Units Equivocal
25.0 Units or greater Positive

Interpretive Data

Saccharomyces cerevisiae IgG antibodies are found in 60-70% of Crohn disease (CD) patients and 10-15% of ulcerative colitis (UC) patients. Saccharomyces cerevisiae IgA antibodies are found in about 35% of CD patients but less than 1% in UC patients. Detection of both Saccharomyces IgG and IgA antibodies in the same serum specimen is highly specific for CD.

Compliance Category

FDA

Note

This test may be a useful tool for distinguishing ulcerative colitis (UC) from Crohn disease (CD) in patients with suspected inflammatory bowel disease.

Hotline History
N/A
CPT Codes

86671 x2

Components
Component Test Code* Component Chart Name LOINC
0050562 S. cerevisiae Antibody, IgG 47321-5
0050563 S. cerevisiae Antibody, IgA 47320-7
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • ASCA
  • ASCA Abs
  • ASCA IgA
  • ASCA IgG
  • S. cerevisiae
Saccharomyces cerevisiae Antibodies, IgG & IgA