Ordering Recommendation

Not recommended as a standalone test. If using serology testing, IgM combined with IgG is preferred. Do not use for diagnosis in immunocompromised individuals. Preferred test for detecting CMV infection is Cytomegalovirus by Quantitative PCR (0051813).

Mnemonic
CMV IGM
Methodology

Semi-Quantitative Chemiluminescent Immunoassay

Performed

Sun-Sat

Reported

Within 24 hours

New York DOH Approval Status
This test is New York DOH approved.
Specimen Required
Patient Preparation
Collect

Serum Separator Tube (SST).

Specimen Preparation

Allow specimen to clot completely at room temperature. Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.5 mL) Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens.

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Contaminated, heat-inactivated or grossly hemolyzed specimens.

Remarks

Label specimens plainly as acute or convalescent.

Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (Avoid repeated freeze/thaw cycles)

Reference Interval
29.9 AU/mL or less: Not Detected.
30.0-34.9 AU/mL: Indeterminate - Repeat testing in 10-14 days may be helpful.
35.0 AU/mL or greater: Detected - IgM antibody to CMV detected, which may indicate a current or recent infection.  However, low levels of IgM antibodies may occasionally persist for more than 12 months post-infection.

Interpretive Data

CMV serology is not useful for the evaluation of active or reactivated infection in immunocompromised patients. Molecular diagnostic tests (i.e., PCR) are preferred in these cases.

This test should not be used for blood donor screening, associated re-entry protocols, or for screening Human Cell, Tissues and Cellular and Tissue-Based Products (HCT/P).

Compliance Category

FDA

Note
Hotline History
N/A
CPT Codes

86645

Components
Component Test Code* Component Chart Name LOINC
0050553 CMV Antibody IgM 7853-5
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.
Aliases
  • CMV
  • CMV Antibody
  • CMV IgM
Cytomegalovirus Antibody, IgM