0050292
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Herpes Simplex Virus Type 1 Glycoprotein G-Specific Antibody, IgG by CIA

HERP I
Example Reports
Negative
Positive

Ordering Recommendation

Not a stand-alone test. Order in conjunction with Herpes Simplex Virus Type 2 Glycoprotein G-Specific Antibody, IgG by CIA (0050294). Because glycoprotein antibodies may require 3-6 months to form, follow-up testing is recommended to confirm a negative IgG glycoprotein result in the context of positive HSV Types 1 or 2 antibody results.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube (SST).

Specimen Preparation

Allow specimen to clot completely at room temperature. Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP standard transport tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Contaminated, heat-inactivated, grossly hemolyzed, lipemic, or severely icteric specimens.

Remarks
Stability

After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Methodology

Semi-Quantitative Chemiluminescent Immunoassay (CLIA)

Performed

Sun-Sat

Reported

1-2 days

Reference Interval

Effective February 18, 2020
0.89 IV or less Negative - No significant level of detectable IgG antibody to HSV type 1 glycoprotein G.
0.90-1.09 IV Equivocal - Questionable presence of IgG antibody to HSV type 1 glycoprotein G. Repeat testing in 10-14 days may be helpful.
1.10 IV or greater Positive - IgG antibody to HSV type 1 glycoprotein G detected, which may indicate a current or past HSV infection.

Interpretive Data

  Individuals infected with HSV may not exhibit detectable IgG antibody to type-specific HSV antigens 1 and 2 in the early stages of infection. Detection of antibody presence in these cases may only be possible using a nontype-specific screening test.

False positive results are possible. Consider additional testing for results less than or equal to 3.0 IV for type specific assays.

Compliance Category

FDA

Note

For CSF Specimens, refer to Herpes Simplex Virus Type 1 Glycoprotein G-Specific Antibody, IgG by ELISA, CSF (ARUP test code 0050379).

Hotline History

N/A

CPT Codes

86695

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Components

Component Test Code* Component Chart Name LOINC
0050292 HSV 1 Glycoprotein G Ab, IgG 42337-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • HerpeSelect
  • HSV-1
  • HSV 1
  • HSV Type 1 IgG Specific Ab
  • HSV Type 1 glycoprotein G
  • HSV typing 1
Herpes Simplex Virus Type 1 Glycoprotein G-Specific Antibody, IgG by CIA