Ordering Recommendation

Not a stand-alone test. Order in conjunction with Herpes Simplex Virus Type 2 Glycoprotein G-Specific Antibody, IgG by CIA (0050294). Because glycoprotein antibodies may require 3-6 months to form, follow-up testing is recommended to confirm a negative IgG glycoprotein result in the context of positive HSV Types 1 or 2 antibody results.




Semi-Quantitative Chemiluminescent Immunoassay




1-2 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation

Serum Separator Tube (SST).

Specimen Preparation

Allow specimen to clot completely at room temperature. Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport tube. (Min: 0.5 mL)

Storage/Transport Temperature


Unacceptable Conditions

Contaminated, heat-inactivated, grossly hemolyzed, lipemic, or severely icteric specimens.


After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval

Effective February 18, 2020
0.89 IV or less Negative - No significant level of detectable IgG antibody to HSV type 1 glycoprotein G.
0.90-1.09 IV Equivocal - Questionable presence of IgG antibody to HSV type 1 glycoprotein G. Repeat testing in 10-14 days may be helpful.
1.10 IV or greater Positive - IgG antibody to HSV type 1 glycoprotein G detected, which may indicate a current or past HSV infection.

Interpretive Data

Individuals infected with HSV may not exhibit detectable IgG antibody to type-specific HSV antigens 1 and 2 in the early stages of infection. Detection of antibody presence in these cases may only be possible using a non-type specific screening test.

Compliance Category



For CSF Specimens, refer to Herpes Simplex Virus Type 1 Glycoprotein G-Specific Antibody, IgG by ELISA, CSF (ARUP test code 0050379).

Hotline History


CPT Codes



Component Test Code* Component Chart Name LOINC
0050292 HSV 1 Glycoprotein G Ab, IgG 42337-6
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.


  • HerpeSelect
  • HSV 1
  • HSV Type 1 glycoprotein G
  • HSV Type 1 IgG Specific Ab
  • HSV typing 1
  • HSV-1
Herpes Simplex Virus Type 1 Glycoprotein G-Specific Antibody, IgG by CIA