Ordering Recommendation

Use to screen for the presence of coccidioidal IgG antibodies in serum. Not recommended as a standalone test. For screening with confirmation, refer to Coccidioides Antibodies Reflexive Panel, Serum (3001982).

Mnemonic

COCCI G

Methodology

Enzyme-Linked Immunosorbent Assay (ELISA)

Performed

Sun-Sat

Reported

1-3 days

New York DOH Approval Status

This test is New York DOH approved.

Specimen Required

Patient Preparation
Collect

Serum Separator Tube (SST).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL). Parallel testing is preferred and convalescent specimens must be received within 30 days from receipt of the acute specimens.

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Other body fluids. Contaminated, hemolyzed, icteric, or lipemic specimens.

Remarks

Mark specimens plainly as acute or convalescent.

Stability

Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval

0.9 IV or less Negative - No significant level of Coccidioides IgG antibody detected.
1.0-1.4 IV Equivocal - Questionable presence of Coccidioides IgG antibody detected.  Repeat testing in 10-14 days may be helpful.
1.5 IV or greater Positive - Presence of IgG antibody to Coccidioides detected, suggestive of current or past infection.

Interpretive Data

IgG antibody usually appears by the third week of infection and may persist for years.  Both tube precipitin (TP) and CF antigens are represented in the ELISA tests.

Compliance Category

FDA

Note

This immunoassay uses recombinant and native Coccidioides antigens, including CF and TP antigens.

Hotline History

N/A

CPT Codes

86635

Components

Component Test Code* Component Chart Name LOINC
0050179 Coccidioides Antibody, IgG by ELISA 27009-0
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • CF
  • Coccidioides immitis
  • Coccidioidomycosis
  • Precipitin
  • TP
  • Valley fever
Coccidioides Antibodies, IgG by Immunoassay, Serum